Molecular Separation by Using Active and Passive Microfluidic chip Designs: A Comprehensive Review

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dc.authoridEbrahimi, Aliakbar/0000-0001-6437-7796
dc.authoridÖzel, Ceren/0000-0002-5648-3174
dc.authoridDoğan Güzel, Fatma/0000-0001-7200-4615
dc.authoridGulec, Kadri/0000-0002-1392-8276
dc.authoridTarim, Ergun Alperay/0000-0003-3455-3167
dc.authorwosidEbrahimi, Aliakbar/GLS-6693-2022
dc.authorwosidÖzel, Ceren/HKE-8249-2023
dc.authorwosidTayybi Azer, Mehdi/JWO-3408-2024
dc.authorwosidGhorbanpoor, Hamed/KBQ-7545-2024
dc.authorwosidDoğan Güzel, Fatma/KDO-5399-2024
dc.contributor.authorEbrahimi, Aliakbar
dc.contributor.authorIcoz, Kutay
dc.contributor.authorDidarian, Reza
dc.contributor.authorShih, Chih-Hsin
dc.contributor.authorTarim, E. Alperay
dc.contributor.authorNasseri, Behzad
dc.contributor.authorAkpek, Ali
dc.date.accessioned2024-05-19T14:38:48Z
dc.date.available2024-05-19T14:38:48Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractSeparation and identification of molecules and biomolecules such as nucleic acids, proteins, and polysaccharides from complex fluids are known to be important due to unmet needs in various applications. Generally, many different separation techniques, including chromatography, electrophoresis, and magnetophoresis, have been developed to identify the target molecules precisely. However, these techniques are expensive and time consuming. Lab-on-a-chip systems with low cost per device, quick analysis capabilities, and minimal sample consumption seem to be ideal candidates for separating particles, cells, blood samples, and molecules. From this perspective, different microfluidic-based techniques have been extensively developed in the past two decades to separate samples with different origins. In this review, lab-on-a-chip methods by passive, active, and hybrid approaches for the separation of biomolecules developed in the past decade are comprehensively discussed. Due to the wide variety in the field, it will be impossible to cover every facet of the subject. Therefore, this review paper covers passive and active methods generally used for biomolecule separation. Then, an investigation of the combined sophisticated methods is highlighted. The spotlight also will be shined on the elegance of separation successes in recent years, and the remainder of the article explores how these permit the development of novel techniques. This review is about the microfludic-based methods that have been used in the past two decades for the separation of different biomolecules like protein, DNA, and RNA. In this regard, passive, active, and hybrid microfludic methods that are used for biomolecules separation are disscused and reviewed in this paper.imageen_US
dc.description.sponsorshipTurkish Scientific and Technological Council (TUBITAK); Ministry of Science and Technology, Taiwan; Scientific and Technological Research Council of Turkey; Outstanding Young Scientists Award from the Turkish Academy of Science; Turkish Council of Higher Education; Turkish Scientific and Technological Council; Scientific Research Projects (BAP- the priority areas project (ONAP) of Eskisehir Osmangazi University; Yildiz Technical University Scientific Research Projects; [119N608]; [MOST 109-2221-E-035-036-MY3]; [MOST 110-2124-M-005-001-MY3]; [119M052]; [222M468]; [20AG003]; [20AG031]; [TOA-2022-2307]; [TYL-2023-2720]; [TSA-2022-5317]en_US
dc.description.sponsorshipThis study was supported by the Turkish Scientific and Technological Council (TUBITAK) under the grant numbers of 119N608. Y.C.E.L. would like to thank the Ministry of Science and Technology, Taiwan (MOST 109-2221-E-035-036-MY3, and MOST 110-2124-M-005-001-MY3), for supporting this work. H.C.T. acknowledges financial support from The Scientific and Technological Research Council of Turkey (grant number 119M052). H.C.T. would like to thank Outstanding Young Scientists Award funding (TUBA GEBIP 2020) from the Turkish Academy of Science. E.A.T. and C.OE. acknowledge the support of The Scientific and Technological Research Council of Turkey for 2211-A BIDEB doctoral scholarship, and Turkish Council of Higher Education for 100/2000 CoHE doctoral scholarship. H.G. would like to thank The Scientific and Technological Research Council of Turkey (grant number 222M468) for supporting this work. This study was supported by Turkish Scientific and Technological Council (TUBITAK 1004- Regenerative and Restorative Medicine Research and Applications) under the grant numbers of 20AG003 and 20AG031 and Scientific Research Projects (BAP- the priority areas project (ONAP) under the grant number of TOA-2022-2307 and TYL-2023-2720 of Eskisehir Osmangazi University. This study was supported by Yildiz Technical University Scientific Research Projects with the project number TSA-2022-5317.en_US
dc.identifier.doi10.1002/admi.202300492
dc.identifier.issn2196-7350
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85174895341en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org10.1002/admi.202300492
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4615
dc.identifier.volume11en_US
dc.identifier.wosWOS:001088515100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAdvanced Materials Interfacesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectActive Separationen_US
dc.subjectBiomolecule Separationen_US
dc.subjectHybrid Separationen_US
dc.subjectLab-On-A-Chipen_US
dc.subjectMicrofluidicsen_US
dc.subjectPassive Separationen_US
dc.titleMolecular Separation by Using Active and Passive Microfluidic chip Designs: A Comprehensive Reviewen_US
dc.typeReview Articleen_US

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