Synthesis of Isotopic Labelled Paracetamol Benzoate-d3 and Its Application in the Determination of Paracetamol

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dc.authoridBAKIRDERE, Sezgin/0000-0001-9746-3682
dc.authoridERARPAT BODUR, Sezin/0000-0002-9879-6662
dc.authoridBodur, Süleyman/0000-0002-2994-9047
dc.authorwosidBAKIRDERE, Sezgin/ABU-6359-2022
dc.authorwosidERARPAT BODUR, Sezin/AAZ-6733-2020
dc.authorwosidBodur, Süleyman/AHB-4581-2022
dc.contributor.authorDemirel, Rabia
dc.contributor.authorErarpat, Sezin
dc.contributor.authorBodur, Suleyman
dc.contributor.authorGunkara, Omer Tahir
dc.contributor.authorBakirdere, Sezgin
dc.contributor.authorTurak, Fatma
dc.date.accessioned2024-05-19T14:39:18Z
dc.date.available2024-05-19T14:39:18Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractThis study proposed a precise/accurate analytical method for the paracetamol (PCT) determination in human serum/urine matrices. PCT was simultaneously derivatized and preconcentrated by dispersive liquid-liquid microextraction (DLLME). Benzoyl chloride dissolved in dichloromethane was used as derivatization agent in the extraction solvent. Quadruple isotope dilution (QID) method with three calibration mixtures (A*B-x, x=1,2,3) and one sample mixture (AB) was performed to enhance the method accuracy and precision. In our research laboratory, paracetamol benzoate-d3 (PCT benzoate-d3) was synthesized and used as isotopically labelled substance (B) to conduct QID method. After the combination of QID and DLLME-GC-MS systems, percent recovery results for human serum/urine matrices were found to be 99.3-101.0 % and 98.8-99.9 %, respectively.en_US
dc.description.sponsorshipYildiz Technical University Scientific Research Project [FBA-2021-4215]en_US
dc.description.sponsorshipAcknowledgments This study was funded by Yildiz Technical University Scientific Research Project with the project number FBA-2021-4215.en_US
dc.identifier.doi10.1002/slct.202203851
dc.identifier.issn2365-6549
dc.identifier.issue13en_US
dc.identifier.scopus2-s2.0-85152065149en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org10.1002/slct.202203851
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4751
dc.identifier.volume8en_US
dc.identifier.wosWOS:000961564300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemistryselecten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectBenzoyl Chlorideen_US
dc.subjectDeterminationen_US
dc.subjectGc-Msen_US
dc.subjectIsotope Dilutionen_US
dc.subjectParacetamolen_US
dc.titleSynthesis of Isotopic Labelled Paracetamol Benzoate-d3 and Its Application in the Determination of Paracetamolen_US
dc.typeArticleen_US

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