Endogenous retrovirus HERV-K6 and HERV-K11 polymorphisms’ analyses in head and neck squamous cell carcinoma patients

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dc.authoridElif Karlık / 0000-0003-0669-2725en_US
dc.authoridOrkun Gürbüz / 0000-0001-7488-4361en_US
dc.authoridYemliha Yıldız / 0000-0002-1741-0503en_US
dc.authorscopusidElif Karlık / 56926577900
dc.authorscopusidOrkun Gürbüz / 57225777041
dc.authorscopusidYemliha Yıldız / 35222814800
dc.authorscopusidNermin Gözükırmızı / 6701520637
dc.authorwosidElif Karlık / N-6348-2018
dc.authorwosidOrkun Gürbüz / AGW-8435-2022
dc.authorwosidYemliha Yıldız / CIP-3948-2022
dc.authorwosidNermin Gözükırmızı / DXX-2404-2022
dc.contributor.authorKarlık, Elif
dc.contributor.authorGürbüz, Orkun
dc.contributor.authorYıldız, Yemliha
dc.contributor.authorGözükırmızı, Nermin
dc.date.accessioned2021-03-15T13:50:20Z
dc.date.available2021-03-15T13:50:20Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Eczane Hizmetleri Bölümüen_US
dc.description.abstractMany tumors, such as melanoma, breast cancer, germ cell tumors, renal cancer or ovarian cancer, express HERV proteins, mainly HERV-K (HML6) and HERV-K (HML2). However, there is no report showing any relation between squamous cell carcinoma of head and neck (HNSCC) and HERVs in literature. Here we report the polymorphic changes of HERV-K6 and HERV-K11 in tumor tissue samples of HNSCC patients comparing with healthy individuals. For this purpose, genomic DNAs from tumor tissue samples of 2 healthy individuals and of 8 HNSCC patients were isolated and IRAP-PCR was performed. IRAP-PCR analyses demonstrated that there were 18–73% polymorphism rates for HERV-K6 and 38–100% polymorphism rates for HERV-K11 among all the samples. There were also polymorphic changes between two control materials. Therefore, HERV-K6 polymorphisms may arise on an individual-specific basis. In the previous studies, some associations have been reported between the expression of HERVs and some cancer types or other major diseases. However, few reports have analyzed HERV-K movements among HNSCC patients. This report is the first study investigating HERV-K6 and HERV-K11 retrotransposon polymorphic changes in HNSCC patients.en_US
dc.identifier.citationKarlik, E., Gurbuz, O., Yildiz, Y., & Gozukirmizi, N. (2021). Endogenous retrovirus HERV-K6 and HERV-K11 polymorphisms’ analyses in head and neck squamous cell carcinoma patients. Meta Gene, 100876.en_US
dc.identifier.doi10.1016/j.mgene.2021.100876en_US
dc.identifier.issn2214-5400en_US
dc.identifier.scopus2-s2.0-85101550114en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.1016/j.mgene.2021.100876
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1582
dc.identifier.volume28en_US
dc.identifier.wosWOS:000641584300007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKarlık, Elif
dc.institutionauthorGürbüz, Orkun
dc.institutionauthorYıldız, Yemliha
dc.institutionauthorGözükırmızı, Nermin
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofMeta Geneen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndogenous Retrovirusesen_US
dc.subjectHERVen_US
dc.subjectHNSCCen_US
dc.subjectIRAPen_US
dc.subjectPolymorphismen_US
dc.titleEndogenous retrovirus HERV-K6 and HERV-K11 polymorphisms’ analyses in head and neck squamous cell carcinoma patientsen_US
dc.typeArticleen_US

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