A Cicada Antimicrobial Peptide, Cryptonin, Exhibits Potent Antitumor Activity by Necrosis on Human Melanoma Cells

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dc.authoridTorkay, Gülşah/0000-0002-6803-494X
dc.authorwosidTorkay, Gülşah/IUP-3797-2023
dc.contributor.authorSancar, Serap
dc.contributor.authorTorkay, Gulsah
dc.contributor.authorCan, Tuba
dc.date.accessioned2024-05-19T14:45:47Z
dc.date.available2024-05-19T14:45:47Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractAntimicrobial peptides are the first defense molecules against various organisms such as bacteria, fungi and are produced by different organisms. In this study, we aimed to investigate the anticancer effects of an insect antimicrobial peptide, cryptonin isolated from the hemolymph of cicada, Cryptotympana dubia on malignant melanoma cells. Cryptonin decreased the cell viability in a dose and time-dependent manner and these effects are more in metastatic cells than in other cell lines. The release of LDH from damaged cells and the detection of HMGB1 in cell culture media after peptide treatment indicated that cryptonin could induce cell necrosis and this cell death may activate an immune response. The peptide also increased the necrotic cell nucleus stained with ethidium bromide. According to reactive oxygen species production and mitochondrial membrane depolarization results, the apoptotic effect of the peptide was low in melanoma cells. Although the peptide killed the keratinocytes in vitro, cryptonin or cryptonin- derived peptide may have potential use in the treatment of malignant melanoma.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [2210/A]; General Domestic Graduate Scholarship Program [:1649B022101483, 1649B022113419]en_US
dc.description.sponsorshipG. Torkay and T. Can would like to acknowledge the financial supports from the Scientific and Technological Research Council of Turkey (TUBITAK) 2210/A General Domestic Graduate Scholarship Program (App No:1649B022101483 and 1649B022113419).en_US
dc.identifier.doi10.1007/s10989-023-10540-3
dc.identifier.issn1573-3149
dc.identifier.issn1573-3904
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85162111476en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org10.1007/s10989-023-10540-3
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5345
dc.identifier.volume29en_US
dc.identifier.wosWOS:001009428600001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Journal of Peptide Research and Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectMelanomaen_US
dc.subjectInsect Antimicrobial Peptidesen_US
dc.subjectCryptonin Cell Deathen_US
dc.titleA Cicada Antimicrobial Peptide, Cryptonin, Exhibits Potent Antitumor Activity by Necrosis on Human Melanoma Cellsen_US
dc.typeArticleen_US

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