Dispersive solid phase extraction and quadruple isotope dilution–mass spectrometry combination for the accurate and sensitive quantification of capsaicin in pepper, domestic wastewater and human saliva samples by GC–MS system

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dc.authorscopusidSüleyman Bodur / 57202493954
dc.authorwosidSüleyman Bodur / AHB-4581-2022
dc.contributor.authorBodur, Süleyman
dc.contributor.authorBodur, Sezin Erarpat
dc.contributor.authorGürsoy, Selim
dc.contributor.authorAyyıldız, Merve Fırat
dc.contributor.authorKartoğlu, Bedrihan
dc.contributor.authorAkbıyık, Hilal
dc.contributor.authorGünkara, Ömer Tahir
dc.contributor.authorBakırdere, Sezgin
dc.date.accessioned2025-04-18T09:16:31Z
dc.date.available2025-04-18T09:16:31Z
dc.date.issued2025
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Temel Bilimleri Bölümü
dc.description.abstractIn the presented study, reduced graphene oxide/Fe3O4 (rGO/Fe3O4) nanocomposites based dispersive solid phase extraction (DSPE) – gas chromatography–mass spectrometry (GC–MS) method was developed for the determination of capsaicin in domestic wastewater (DW), pepper (PP) and human saliva (HS) samples. All important parameters of the DSPE method affected the preconcentration factor were carefully optimized to achieve high signal to noise ratio for the analyte. After the optimization studies, the system analytical performance of DSPE-GC–MS system was evaluated using the aqueous standard solution of capsaicin. Limit of detection (LOD), limit of quantitation (LOQ) and dynamic range were figured out to be 0.54 µg/kg, 1.80 µg/kg and 2.66 – 487.35 µg/kg, respectively. Under the optimum experimental conditions, recovery studies were conducted with the spiked DW, PP and HS samples, and percent recovery results were recorded between 52.6 % and 183.6 % via matrix matching calibration strategy. After the implementation of ID4 strategy, percent recovery results for the spiked DW, PP and HS samples were calculated as 98.2 %–99.3 %, 99.7 %–100.7 % and 99.4 %–99.8 %, respectively. In addition, capsaicin content in Sivri (S)-PP, Kıl (K)-PP and Samandağ (SA)-PP samples were found to be 309.5 ± 11.8 mg/kg, 873.7 ± 26.7 mg/kg and 165.3 ± 5.1 mg/kg via DSPE-GC-ID4-MS method, respectively. As a result, the combination of quadruple isotope dilution (ID4) strategy and the DSPE-GC–MS method were successfully performed to boost the accuracy and precision of developed DSPE-GC–MS method. © 2024 Elsevier B.V.
dc.description.sponsorshipThis study was supported with project number of 122Z041 by The Scientific and Technological Research Council of Turkey (T\u00DCB\u0130TAK).
dc.identifier.citationBodur, S., Bodur, S. E., Gürsoy, S., Ayyıldız, M. F., Kartoğlu, B., Akbıyık, H., ... & Bakırdere, S. (2025). Dispersive solid phase extraction and quadruple isotope dilution–mass spectrometry combination for the accurate and sensitive quantification of capsaicin in pepper, domestic wastewater and human saliva samples by GC–MS system. Microchemical Journal, 208, 112246.
dc.identifier.doi10.1016/j.microc.2024.112246
dc.identifier.issn0026265X
dc.identifier.scopus2-s2.0-85210536558
dc.identifier.scopusqualityQ1
dc.identifier.urihttp://dx.doi.org/10.1016/j.microc.2024.112246
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6741
dc.identifier.volume208
dc.indekslendigikaynakScopus
dc.institutionauthorBodur , Süleyman
dc.institutionauthoridSüleyman Bodur / 0000-0002-2994-9047
dc.language.isoen
dc.publisherElsevier Inc.
dc.relation.ispartofMicrochemical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCapsaicin
dc.subjectDispersive Solid Phase Extraction
dc.subjectDomestic Wastewater
dc.subjectPepper
dc.subjectQuadruple İsotope Dilution
dc.titleDispersive solid phase extraction and quadruple isotope dilution–mass spectrometry combination for the accurate and sensitive quantification of capsaicin in pepper, domestic wastewater and human saliva samples by GC–MS system
dc.typeArticle

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