The inhibition of RXRα and RXRβ receptors provides valuable insights for potential prostate cancer treatment, in silico molecular docking and molecular dynamics studies

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dc.authorscopusidEngin Ulukaya / 6602927353
dc.authorwosidEngin Ulukaya / K-5792-2018
dc.contributor.authorAgar, Soykan
dc.contributor.authorAkkurt, Barbaros
dc.contributor.authorUlukaya, Engin
dc.date.accessioned2025-04-18T09:06:46Z
dc.date.available2025-04-18T09:06:46Z
dc.date.issued2024
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractIntroduction: Prostate cancer has emerged as a widespread health concern, with systemic inflammation believed to substantially contribute to its development and progression. The presence of systemic inflammatory responses has been established as an independent predictor of unfavorable long-term outcomes in prostate cancer patients. The goal of this study is to inhibit RXRα and RXRβ receptors, which are involved in prostate cancer, with Luteolin, Formononetin, and Kaempferol, with varying success. Methods: Retinoid X receptors (RXRs) hold crucial roles within the nuclear receptor (NR) superfamily, and compelling evidence from preclinical studies underscores the therapeutic potential of targeting RXRs for treating neurodegenerative and inflammatory conditions. Consequently, the ability to regulate and modulate RXRs using phytoestrogen ligands, Formononetin, Kaempferol, and Luteolin, assume paramount importance in treatment strategies. Results: The comprehensive in silico findings of this study vividly demonstrate the remarkable efficacy of Luteolin in inhibiting and modulating RXRα and RXRβ, while Formononetin emerges as a notably potent suppressor of RXRβ. Kaempferol, as the third compound, also exhibits commendable inhibitory attributes, although its impact is slightly less pronounced compared to the other two. Discussion: These findings highlight the notable binding and inhibition capabilities to RXRα and RXRβ, offering valuable insights for potential prostate cancer treatment avenues warranting further exploration through in vitro and in vivo analyses.
dc.identifier.citationErsin, Ö. Ö., Ustabaş, A., & Usman, O. (2024). The role of environmental innovation on ecologic footprint in nations with high technology exports concentrations in international trade. Technological Forecasting and Social Change, 208, 123703.
dc.identifier.doi10.31557/APJCP.2024.25.7.2329
dc.identifier.endpage2335
dc.identifier.issn15137368
dc.identifier.issue7
dc.identifier.pmid39068565
dc.identifier.scopus2-s2.0-85199936316
dc.identifier.scopusqualityQ3
dc.identifier.startpage2329
dc.identifier.urihttp://dx.doi.org/10.31557/APJCP.2024.25.7.2329
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6693
dc.identifier.volume25
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorUlukaya, Engin
dc.institutionauthoridEngin Ulukaya / 0000-0003-4875-5472
dc.language.isoen
dc.publisherAsian pacific organization for cancer prevention
dc.relation.ispartofAsian pacific journal of cancer prevention
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIn Silico Molecular Docking
dc.subjectMolecular Dynamics
dc.subjectProstate Cancer RXR Receptors
dc.titleThe inhibition of RXRα and RXRβ receptors provides valuable insights for potential prostate cancer treatment, in silico molecular docking and molecular dynamics studies
dc.typeArticle

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