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Öğe Comparison of novel Martin/Hopkins and sampson equations for calculation of low-density lipoprotein cholesterol in diabetic patients(ARQUIVOS BRASILEIROS CARDIOLOGIA, 2022) Naser, Abdulrahman; Isgandarov, Khagani; Güvenç, Tolga Sinan; Güvenç, Rengin Çetin; Şahin, MüslümBackground: The accurate determination of low-density lipoprotein cholesterol (LDL-C) is important to reach guidelinere-commended LDL-C concentrations and to reduce adverse cardiovascular outcomes in diabetic patients. The commonly used Friedewald equation (LDL-Cf), gives inaccurate results in diabetic patients due to accompanying diabetic dyslipidemia. Recently two new equations - Martin/Hopkins (LDL-Cmh) and Sampson (LDL-Cs) - were developed to improve the accuracy of LDL-C estimation, but data are insufficient to suggest the superiority of one equation over the other one. Objective: The present study compared the accuracy and clinical usefulness of novel Martin/Hopkins and Sampson equations in diabetic patients. Methods: This study included 402 patients with diabetes. Patients' cardiovascular risk and LDL-C targets were calculated per European guidelines. Calculated LDL-Cmh, LDL-Cs, and LDL-Cf concentrations were compared with direct LDL-C concentration (LDL-Cd) to test agreement between these equations and LDL-Cd. A p-value <0.05 was accepted as statistically significant. Results: Both LDL-Cmh and LDL-Cs had a better agreement with LDL-Cd as compared to LDL-Cf, but no statistical differences were found among novel equations for agreement with LDL-Cd (Cronbach's alpha 0.955 for both, p=1). Likewise, LDL-Cmh and LDL-Cs showed a similar degree of agreement with LDL-Cd in determining whether a patient was in a guideline-recommended LDL-C target (96.3% for LDL-Cmh and 96.0% for LDL- Cs), which were marginally better than LDL-Cf (94.6%). In patients with a triglyceride concentration >400 mg/dl, agreement with LDL-Cd was poor, regardless of the method used. Conclusion: Martin/Hopkins and Sampson's equations show a similar accuracy for calculating LDL-C concentrations in patients with diabetes, and both equations were marginally better than the Friedewald equation.Öğe Formulating and characterizing an exosome-based dopamine carrier system(Jove, 2022) Naser, Abdulrahman; Isgandarov, Khagani; Güvenç, Tolga Sinan; Ekmekçi, Ahmet; Güvenç, Rengin Çetin; Şahin, Müslüm; Gündüz, Sabahattin; Şahin, MüslümExosomes between 40 and 200 nm in size constitute the smallest subgroup of extracellular vesicles. These bioactive vesicles secreted by cells play an active role in intercellular cargo and communication. Exosomes are mostly found in body fluids such as plasma, cerebrospinal fluid, urine, saliva, amniotic fluid, colostrum, breast milk, joint fluid, semen, and pleural acid. Considering the size of exosomes, it is thought that they may play an important role in central nervous system diseases because they can pass through the blood-brain barrier (BBB). Hence, this study aimed to develop an exosome-based nanocarrier system by encapsulating dopamine into exosomes isolated from Wharton's jelly mesenchymal stem cells (WJ-MSCs). Exosomes that passed the characterization process were incubated with dopamine. The dopamine-loaded exosomes were recharacterized at the end of incubation. Dopamine-loaded exosomes were investigated in drug release and cytotoxicity assays. The results showed that dopamine could be successfully encapsulated within the exosomes and that the dopamine-loaded exosomes did not affect fibroblast viability.Öğe Lack of right ventricular hypertrophy is associated with right heart failure in patients with left ventricular failure(Springer, 2022) Naser, Abdulrahman; Isgandarov, Khagani; Güvenç, Tolga Sinan; Ekmekçi, Ahmet; Gündüz, Sabahattin; Güvenç, Rengin Çetin; Şahin, MüslümPresence of right heart failure (RHF) is associated with a worse prognosis in patients with left ventricular failure (LVF). While the cause of RHF secondary to LVF is multifactorial, an increased right ventricular (RV) afterload is believed as the major cause of RHF. However, data are scarce on the adaptive responses of the RV in patients with LVF. Our aim was to understand the relationship of right ventricular hypertrophy (RVH) with RHF and RV systolic and diastolic properties in patients with LVF. 55 patients with a left ventricular ejection fraction of 40% or less were included in the present study. A comprehensive two-dimensional transthoracic echocardiographic examination was done to all participants. 12 patients (21.8%) had RHF, and patients with RHF had a signifcantly lower right ventricular free wall thickness (RVFWT) as compared to patients without RHF (5.3±1.7 mm vs. 6.6±0.9 mm, p=0.02) and the diference remained statistically signifcant after adjusting for confounders (?x?:1.34 mm, p=0.002). RVFWT had a statistically signifcant correlation with tricuspid annular plane systolic excursion (r=0.479, p<0.001) and tricuspid annular lateral systolic velocity (r=0.360, p=0.007), but not with the indices of the RV diastolic function. None of the patients with concentric RVH had RHF, while 22.2% of patients with eccentric RVH and 66.7% of patients without RVH had RHF (p<0.01 as compared to patients with concentric RVH). In patients with left ventricular systolic dysfunction, absence of RVH was associated with worse RV systolic performance and a signifcantly higher incidence of RHFÖğe The Relationship Between Epicardial Adipose Tissue and Visceral Adiposity Indexes in Individuals Without Established Atherosclerotic Cardiovascular Disease and Diabetes Mellitus(Aves, 2023) Naser, Abdulrahman; Isgandarov, Khagani; Guvenc, Tolga Sinan; Demir, Ibrahim; Kirisci, Murat; Sahin, Muslum; Guvenc, Rengin CetinObjective: Visceral adipose tissue performs an important role in the development of atherosclerotic cardiovascular disease. Expressing its close association with epicardial adipose tissue simplifies the understanding of visceral adipose tissue in terms of atherosclerotic cardiovascular disease risk and facilitates the implementation of necessary lifestyle changes. In this study, we aimed to explore the relationship between epicardial adipose tissue and visceral adipose tissue proxies such as visceral fat rating, visceral adiposity index, and lipid accumulation product index as well as anthropometrics and lipid profile.Methods: This cross-sectional study involved 244 participants (131 female, 113 males), aged 18-83 years without established atherosclerotic cardiovascular disease and diabetes mellitus. Epicardial adipose tissue was measured by transthoracic echocardiography. Visceral fat rating, total body fat percentage, and mass were assessed by a bioimpedance analyzer. Mathematical formulas calculated the visceral adiposity index and lipid accumulation product index. Demographic, clinical, and biochemical information of the participants was provided from the hospital's data system. Homeostasis model assessment of insulin resistance-insulin resistance was calculated using fasting insulin and glucose.Results: Epicardial adipose tissue was significantly correlated with the visceral fat rating, visceral adiposity index, lipid accumulation product index, age, body weight, body mass index, waist circumference, waist-to-height ratio, waist-to-hip ratio, total body fat percentage and mass, systolic blood pressure, diastolic blood pressure, fasting glucose, hemoglobin A1c, insulin, homeostasis model assessment of insulin resistance, total cholesterol, low-density lipoprotein cholesterol, triglyceride, high-density lipoprotein cholesterol, and cigarette smoking. Multivariate regression analyses revealed that age (0 = 0.036, P = .001), visceral fat rating (0 = 0.221, P < .001), systolic blood pressure (0 = 0.033, P < .001), diastolic blood pressure (0 = -0.048, P < .001), and cigarette smoking (0 = 0.042, P < .001) were independent variables related to epicardial adipose tissue.Conclusion: Epicardial adipose tissue is associated with cardiovascular disease risk factors and indices of visceral adiposity in people without established atherosclerotic cardiovascular disease and diabetes mellitus.Öğe Transcutaneous puncture and successfully retrieval of undeflated peripheral angioplasty balloon(NLM (Medline), 2022) Isgandarov, Khagani; Naser, Abdulrahman; Şahin, Müslüm; Güvenç, Tolga SinanPercutaneous transluminal angioplasty has gained increasing popularity in the treatment of peripheral artery disease. However, the increase in the frequency of this procedure also increases the risk of complications. Percutaneous transluminal angioplasty has serious and general complications in terms of device and technique at puncture and dilatation sites. In this case, we describe the easy and practical management of deflating an undeflated ballon in the right superficial femoral artery.
