Comparison of novel Martin/Hopkins and sampson equations for calculation of low-density lipoprotein cholesterol in diabetic patients
Yükleniyor...
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ARQUIVOS BRASILEIROS CARDIOLOGIA
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: The accurate determination of low-density lipoprotein cholesterol (LDL-C) is important to reach guidelinere-commended LDL-C concentrations and to reduce adverse cardiovascular outcomes in diabetic patients. The commonly used Friedewald equation (LDL-Cf), gives inaccurate results in diabetic patients due to accompanying diabetic dyslipidemia. Recently two new equations - Martin/Hopkins (LDL-Cmh) and Sampson (LDL-Cs) - were developed to improve the accuracy of LDL-C estimation, but data are insufficient to suggest the superiority of one equation over the other one. Objective: The present study compared the accuracy and clinical usefulness of novel Martin/Hopkins and Sampson equations in diabetic patients. Methods: This study included 402 patients with diabetes. Patients' cardiovascular risk and LDL-C targets were calculated per European guidelines. Calculated LDL-Cmh, LDL-Cs, and LDL-Cf concentrations were compared with direct LDL-C concentration (LDL-Cd) to test agreement between these equations and LDL-Cd. A p-value <0.05 was accepted as statistically significant. Results: Both LDL-Cmh and LDL-Cs had a better agreement with LDL-Cd as compared to LDL-Cf, but no statistical differences were found among novel equations for agreement with LDL-Cd (Cronbach's alpha 0.955 for both, p=1). Likewise, LDL-Cmh and LDL-Cs showed a similar degree of agreement with LDL-Cd in determining whether a patient was in a guideline-recommended LDL-C target (96.3% for LDL-Cmh and 96.0% for LDL- Cs), which were marginally better than LDL-Cf (94.6%). In patients with a triglyceride concentration >400 mg/dl, agreement with LDL-Cd was poor, regardless of the method used. Conclusion: Martin/Hopkins and Sampson's equations show a similar accuracy for calculating LDL-C concentrations in patients with diabetes, and both equations were marginally better than the Friedewald equation.
Açıklama
Anahtar Kelimeler
Metabolic Diseases, Atherosclerosis, Dyslipidemias, Coronary Artery Disease, Diabetes Mellitus, Lipoproteins, LDL, Cholesterol, LDL
Kaynak
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
119
Sayı
2
Künye
Naser, A., Isgandarov, K., Guvenc, T. S., Guvenc, R. C., Sahin, M. (2022). Comparison of novel Martin/Hopkins and sampson equations for calculation of low-density lipoprotein cholesterol in diabetic patients. Arquivos Brasileiros de Cardiologia, 119(2), 225-232.
