Comparison of novel Martin/Hopkins and sampson equations for calculation of low-density lipoprotein cholesterol in diabetic patients

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dc.authorwosidMüslüm Şahin / DNT-9358-2022en_US
dc.authorwosidTolga Sinan Güvenç / JQN-5460-2023en_US
dc.contributor.authorNaser, Abdulrahman
dc.contributor.authorIsgandarov, Khagani
dc.contributor.authorGüvenç, Tolga Sinan
dc.contributor.authorGüvenç, Rengin Çetin
dc.contributor.authorŞahin, Müslüm
dc.date.accessioned2022-09-07T11:11:14Z
dc.date.available2022-09-07T11:11:14Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: The accurate determination of low-density lipoprotein cholesterol (LDL-C) is important to reach guidelinere-commended LDL-C concentrations and to reduce adverse cardiovascular outcomes in diabetic patients. The commonly used Friedewald equation (LDL-Cf), gives inaccurate results in diabetic patients due to accompanying diabetic dyslipidemia. Recently two new equations - Martin/Hopkins (LDL-Cmh) and Sampson (LDL-Cs) - were developed to improve the accuracy of LDL-C estimation, but data are insufficient to suggest the superiority of one equation over the other one. Objective: The present study compared the accuracy and clinical usefulness of novel Martin/Hopkins and Sampson equations in diabetic patients. Methods: This study included 402 patients with diabetes. Patients' cardiovascular risk and LDL-C targets were calculated per European guidelines. Calculated LDL-Cmh, LDL-Cs, and LDL-Cf concentrations were compared with direct LDL-C concentration (LDL-Cd) to test agreement between these equations and LDL-Cd. A p-value <0.05 was accepted as statistically significant. Results: Both LDL-Cmh and LDL-Cs had a better agreement with LDL-Cd as compared to LDL-Cf, but no statistical differences were found among novel equations for agreement with LDL-Cd (Cronbach's alpha 0.955 for both, p=1). Likewise, LDL-Cmh and LDL-Cs showed a similar degree of agreement with LDL-Cd in determining whether a patient was in a guideline-recommended LDL-C target (96.3% for LDL-Cmh and 96.0% for LDL- Cs), which were marginally better than LDL-Cf (94.6%). In patients with a triglyceride concentration >400 mg/dl, agreement with LDL-Cd was poor, regardless of the method used. Conclusion: Martin/Hopkins and Sampson's equations show a similar accuracy for calculating LDL-C concentrations in patients with diabetes, and both equations were marginally better than the Friedewald equation.en_US
dc.identifier.citationNaser, A., Isgandarov, K., Guvenc, T. S., Guvenc, R. C., Sahin, M. (2022). Comparison of novel Martin/Hopkins and sampson equations for calculation of low-density lipoprotein cholesterol in diabetic patients. Arquivos Brasileiros de Cardiologia, 119(2), 225-232.en_US
dc.identifier.doi10.36660/abc.20210641en_US
dc.identifier.endpage232en_US
dc.identifier.issn0066-782Xen_US
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85135535968en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage225en_US
dc.identifier.urihttps://doi.org/10.36660/abc.20210641
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3125
dc.identifier.volume119en_US
dc.identifier.wosWOS:000841701300003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorGüvenç, Tolga Sinan
dc.institutionauthorŞahin, Müslüm
dc.language.isoenen_US
dc.publisherARQUIVOS BRASILEIROS CARDIOLOGIAen_US
dc.relation.ispartofARQUIVOS BRASILEIROS DE CARDIOLOGIAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMetabolic Diseasesen_US
dc.subjectAtherosclerosisen_US
dc.subjectDyslipidemiasen_US
dc.subjectCoronary Artery Diseaseen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectLipoproteinsen_US
dc.subjectLDLen_US
dc.subjectCholesterolen_US
dc.subjectLDLen_US
dc.titleComparison of novel Martin/Hopkins and sampson equations for calculation of low-density lipoprotein cholesterol in diabetic patientsen_US
dc.typeArticleen_US

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