Emerging therapies against Naegleria fowleri

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dc.authorscopusidRuqaiyyah Siddiqui / 18635417000
dc.authorscopusidNaveed Ahmed Khan / 7401797675
dc.authorwosidRuqaiyyah Siddiqui / AIF-2100-2022
dc.authorwosidNaveed Ahmed Khan / GWD-0187-2022
dc.contributor.authorSiddiqui, Ruqaiyyah
dc.contributor.authorLloyd, David
dc.contributor.authorAlharbi, Ahmad M.
dc.contributor.authorKhan, Naveed Ahmed
dc.date.accessioned2025-04-18T10:37:51Z
dc.date.available2025-04-18T10:37:51Z
dc.date.issued2024
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractIntroduction Naegleria fowleri is a free-living protist pathogen. Given the opportunity, it can produce infection of the central nervous system. It is distressing that the brain-eating amoebae, Naegleria fowleri remains one of the lethal parasites resulting almost always in death, despite advances in antimicrobial chemotherapy and supportive care. Areas covered The overall aim is to present a timely review of our current understanding of emerging therapies and priorities. By searching bibliographic databases (PubMed) for the available peer-reviewed research literature, herein, we discuss current advances, challenges and opportunities pertinent in the development of therapeutic interventions. Expert opinion The prospect of exploring repurposed drugs in combination with nanotechnology and a theranostic approach to concurrently achieve diagnosis and drug delivery will offer promise in the rational development of effective therapies to counter N. folweri-associated fatal brain infections.
dc.description.sponsorshipUnited States Department of Defense Air Force Office of Scientific Research (AFOSR)
dc.identifier.citationSiddiqui, R., Lloyd, D., Alharbi, A. M., & Khan, N. A. (2024). Emerging therapies against Naegleria fowleri. Expert Opinion on Orphan Drugs, 12(1), 41-49.
dc.identifier.doi10.1080/21678707.2024.2383173
dc.identifier.endpage49
dc.identifier.issn2167-8707
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85200272066
dc.identifier.scopusqualityQ2
dc.identifier.startpage41
dc.identifier.urihttp://dx.doi.org/10.1080/21678707.2024.2383173
dc.identifier.urihttps://hdl.handle.net/20.500.12713/7152
dc.identifier.volume12
dc.identifier.wosWOS:001282386400001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorSiddiqui, Ruqaiyyah
dc.institutionauthorKhan, Naveed Ahmed
dc.institutionauthoridRuqaiyyah Siddiqui / 0000-0001-9646-6208
dc.institutionauthoridNaveed Ahmed Khan / 0000-0001-7667-8553
dc.language.isoen
dc.publisherTaylor & francis ltd
dc.relation.ispartofExpert opinion on orphan drugs
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNaegleria Fowleri
dc.subjectBrain-Eating Amoeba
dc.subjectCNS Infections
dc.subjectFree-Living Amoebae
dc.subjectEmerging Therapies
dc.titleEmerging therapies against Naegleria fowleri
dc.typeArticle

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