Predicting Teeth Extraction after Concurrent Chemoradiotherapy in Locally Advanced Nasopharyngeal Cancer Patients Using the Novel GLUCAR Index

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dc.authoridTopkan, Erkan/0000-0001-8120-7123
dc.authoridselek, ugur/0000-0001-8087-3140
dc.authoridYilmaz, Busra/0000-0003-0633-5648
dc.authoridSomay, efsun/0000-0001-8251-6913
dc.authorwosidTopkan, Erkan/AAG-2213-2021
dc.authorwosidselek, ugur/O-5474-2014
dc.contributor.authorSomay, Efsun
dc.contributor.authorTopkan, Erkan
dc.contributor.authorYilmaz, Busra
dc.contributor.authorBesen, Ali Ayberk
dc.contributor.authorMertsoylu, Huseyin
dc.contributor.authorSelek, Ugur
dc.date.accessioned2024-05-19T14:45:58Z
dc.date.available2024-05-19T14:45:58Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractTo evaluate the value of the newly created GLUCAR index in predicting tooth extraction rates after concurrent chemoradiotherapy (C-CRT) in locally advanced nasopharyngeal carcinomas (LA-NPCs). Methods: A total of 187 LA-NPC patients who received C-CRT were retrospectively analyzed. The GLUCAR index was defined as 'GLUCAR = (Fasting Glucose x CRP/Albumin Ratio) by utilizing measures of glucose, C-reactive protein (CRP), and albumin obtained on the first day of C-CRT. Results: The optimal GLUCAR cutoff was 31.8 (area under the curve: 78.1%; sensitivity: 70.5%; specificity: 70.7%, Youden: 0.412), dividing the study cohort into two groups: GLUCAR < 1.8 (N = 78) and GLUCAR >= 31.8 (N = 109) groups. A comparison between the two groups found that the tooth extraction rate was significantly higher in the group with a GLUCAR >= 31.8 (84.4% vs. 47.4% for GLUCAR < 31.8; odds ratio (OR):1.82; p < 0.001). In the univariate analysis, the mean mandibular dose >= 38.5 Gy group (76.5% vs. 54.9% for <38.5 Gy; OR: 1.45; p = 0.008), mandibular V55.2 Gy group >= 40.5% (80.3 vs. 63.5 for <40.5%, p = 0.004, OR; 1.30), and being diabetic (71.8% vs. 57.9% for nondiabetics; OR: 1.23; p = 0.007) appeared as the additional factors significantly associated with higher tooth extraction rates. All four characteristics remained independent predictors of higher tooth extraction rates after C-CRT in the multivariate analysis (p < 0.05 for each). Conclusions: The GLUCAR index, first introduced here, may serve as a robust new biomarker for predicting post-C-CRT tooth extraction rates and stratifying patients according to their tooth loss risk after treatment.en_US
dc.identifier.doi10.3390/diagnostics13233594
dc.identifier.issn2075-4418
dc.identifier.issue23en_US
dc.identifier.pmid38066835en_US
dc.identifier.scopus2-s2.0-85178953061en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org10.3390/diagnostics13233594
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5407
dc.identifier.volume13en_US
dc.identifier.wosWOS:001119126400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofDiagnosticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectNasopharyngeal Canceren_US
dc.subjectTooth Extractionen_US
dc.subjectGlucoseen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectAlbuminen_US
dc.titlePredicting Teeth Extraction after Concurrent Chemoradiotherapy in Locally Advanced Nasopharyngeal Cancer Patients Using the Novel GLUCAR Indexen_US
dc.typeArticleen_US

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