Simple hematological markers in predicting the severity of transient tachypnea of newborn: new wine in old bottles

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dc.authoridFatih Bolat / 0000-0002-8363-2139
dc.authoridNecla Yüce Haspolat / 0000-0002-1321-5823
dc.authorscopusidFatih Bolat / 35975570200
dc.authorscopusidNecla Yüce Haspolat / 57405024200
dc.authorwosidFatih Bolat / ABP-7488-2022
dc.authorwosidNecla Yüce Haspolat / CTB-7168-2022
dc.contributor.authorBolat, Fatih
dc.contributor.authorYüce Haspolat, Necla
dc.contributor.authorBolat, Güher
dc.contributor.authorŞahin, Murat
dc.date.accessioned2021-12-21T06:05:06Z
dc.date.available2021-12-21T06:05:06Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Hastaneen_US
dc.description.abstractObjectives: To evaluate the validity of red cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and platelet mass index (PMI) of patients with transient tachypnea of the newborn (TTN), and to find out their roles in predicting severity of TTN. Patients and methods: In this prospective study, hematological parameters (RDW, PMI) and ratios (NLR, PLR) of 147 patients with TTN and 147 full-term healthy controls were evaluated and compared at birth and at 72nd h of life. Patient: s with TTN and 147 full-term healthy controls were evaluated and compared at birth and at 72nd hours of life. Results: RDW and NLR were not only significantly higher in patients with TTN at birth (p = 0.001) and at 72nd hours of life (p: 0.001), but also were correlated with days of nasal continuous positive airway pressure therapy, duration of O2 therapy, TTN clinical scores, hospitalization and TTN duration. At a cut-off value of 2.40, NLR had a sensitivity of 82.5% and specificity of 77.5% to predict TTN, the most striking parameter at 72nd hours of life. RDW of 17.75 was also determined as the predictive cutoff value of TTN (sensitivity 72.5%; specificity 67.5%; area under the receiver-operating characteristic curve 0.80; p = 0.001). Multivariate analysis model adjusted for delivery, gestational age, male gender revealed that RDW and NLR were significantly and independently associated with TTN. Conclusion: RDW and NLR both at birth and at 72nd hours of life can be used as biomarkers to distinguish TTN patients from healthy newborns and to predict the severity of TTN.en_US
dc.identifier.citationBolat, F., Haspolat, N. Y., Bolat, G., & Şahin, M. (2021). Simple Hematological Markers in Predicting the Severity of Transient Tachypnea of Newborn: New Wine in Old Bottles. Journal of tropical pediatrics, 67(6),en_US
dc.identifier.doi10.1093/tropej/fmab100en_US
dc.identifier.issue6en_US
dc.identifier.pmid34894149en_US
dc.identifier.scopus2-s2.0-85122540111en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1093/tropej/fmab100
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2330
dc.identifier.volume67en_US
dc.identifier.wosWOS:000745659700003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBolat, Fatih
dc.institutionauthorYüce Haspolat, Necla
dc.language.isoenen_US
dc.publisherOxford Academicen_US
dc.relation.ispartofJournal of Tropical Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleSimple hematological markers in predicting the severity of transient tachypnea of newborn: new wine in old bottlesen_US
dc.typeArticleen_US

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