Synergistic applications of cyclodextrin-based systems and metal-organic frameworks in transdermal drug delivery for skin cancer therapy

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dc.authoridCordani, Marco/0000-0001-9342-4862
dc.authoridCanale, Viviana Claudia/0000-0002-2311-1251
dc.authoridHasanzadeh, Mahdi/0000-0003-4951-8348
dc.authorwosidCordani, Marco/ABF-4669-2021
dc.authorwosidHasanzadeh, Mahdi/B-4640-2015
dc.contributor.authorScattolin, Thomas
dc.contributor.authorTonon, Giovanni
dc.contributor.authorBotter, Eleonora
dc.contributor.authorCanale, Viviana Claudia
dc.contributor.authorHasanzadeh, Mahdi
dc.contributor.authorCuscela, Denise Maria
dc.contributor.authorBuschini, Annamaria
dc.date.accessioned2024-05-19T14:50:39Z
dc.date.available2024-05-19T14:50:39Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractThis review article explores the innovative field of eco-friendly cyclodextrin-based coordination polymers and metal-organic frameworks (MOFs) for transdermal drug delivery in the case of skin cancer therapy. We critically examine the significant advancements in developing these nanocarriers, with a focus on their unique properties such as biocompatibility, targeted drug release, and enhanced skin permeability. These attributes are instrumental in addressing the limitations inherent in traditional skin cancer treatments and represent a paradigm shift towards more effective and patient-friendly therapeutic approaches. Furthermore, we discuss the challenges faced in optimizing the synthesis process for large-scale production while ensuring environmental sustainability. The review also emphasizes the immense potential for clinical applications of these nanocarriers in skin cancer therapy, highlighting their role in facilitating targeted, controlled drug release which minimizes systemic side effects. Future clinical applications could see these nanocarriers being customized to individual patient profiles, potentially revolutionizing personalized medicine in oncology. With further research and clinical trials, these nanocarriers hold the promise of transforming the landscape of skin cancer treatment. With this study, we aim to provide a comprehensive overview of the current state of research in this field and outline future directions for advancing the development and clinical application of these innovative nanocarriers. This review article explores the innovative field of eco-friendly cyclodextrin-based coordination polymers and metal-organic frameworks (MOFs) for transdermal drug delivery in the case of skin cancer therapy.en_US
dc.description.sponsorshipEuropean Union NextGenerationEU/PRTR [RYC2021-031003I, MICIU/AEI/10.13039/501100011033]; [DM 1061/2021]en_US
dc.description.sponsorshipMC is supported by grant RYC2021-031003I funded by MICIU/AEI/10.13039/501100011033 and, by European Union NextGenerationEU/PRTR. VCC is supported with co-funding of the European Union FSE REACT-EU-PON Ricerca e Innovazione 2014-2020, DM 1061/2021.en_US
dc.identifier.doi10.1039/d4tb00312h
dc.identifier.endpage3839en_US
dc.identifier.issn2050-750X
dc.identifier.issn2050-7518
dc.identifier.issue16en_US
dc.identifier.pmid38529820en_US
dc.identifier.scopus2-s2.0-85191321370en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage3807en_US
dc.identifier.urihttps://doi.org10.1039/d4tb00312h
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5771
dc.identifier.volume12en_US
dc.identifier.wosWOS:001190760400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofJournal of Materials Chemistry Ben_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectCd-Mofen_US
dc.subjectGamma-Cyclodextrinen_US
dc.subjectGreen Chemistryen_US
dc.subjectNanoparticlesen_US
dc.subjectInclusionen_US
dc.subjectEncapsulationen_US
dc.subjectComplexationen_US
dc.subjectDoxorubicinen_US
dc.subjectFabricationen_US
dc.subjectCopolymersen_US
dc.titleSynergistic applications of cyclodextrin-based systems and metal-organic frameworks in transdermal drug delivery for skin cancer therapyen_US
dc.typeReview Articleen_US

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