Improving the urine spot protein/creatinine ratio by the estimated creatinine excretion to predict proteinuria in pediatric kidney transplant recipients

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dc.authoridMehmet Taşdemir / 0000-0002-5579-6339en_US
dc.authorscopusidMehmet Taşdemir / 57188732568
dc.authorwosidMehmet Taşdemir / HHX-0612-2022
dc.contributor.authorİncir, Said
dc.contributor.authorTaşdemir, Mehmet
dc.contributor.authorKoçak, Burak
dc.contributor.authorYelken, Berna
dc.contributor.authorArpalı, Emre
dc.contributor.authorAkyollu, Başak
dc.date.accessioned2021-09-20T06:01:57Z
dc.date.available2021-09-20T06:01:57Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Since the daily creatinine excretion rate (CER) is directly affected by muscle mass, which varies with age, gender, and body weight, using the spot protein/creatinine ratio (Spot P/Cr) follow-up of proteinuria may not always be accurate. Estimated creatinine excretion rate (eCER) can be calculated from spot urine samples with formulas derived from anthropometric factors. Multiplying Spot P/Cr by eCER gives the estimated protein excretion rate (ePER). We aimed to determine the most applicable equation for predicting daily CER and examine whether ePER values acquired from different equations can anticipate measured 24 h urine protein (m24 h UP) better than Spot P/Cr in pediatric kidney transplant recipients. Methods: This study enrolled 23 children with kidney transplantation. To estimate m24 h UP, we calculated eCER and ePER values with three formulas adapted to children (Cockcroft-Gault, Ghazali-Barratt, and Hellerstein). To evaluate the accuracy of the methods, Passing-Bablok and Bland-Altman analysis were used. Results: A statistically significant correlation was found between m24 h UP and Spot P/Cr (p < .001, r = 0.850), and the correlation was enhanced by multiplying the Spot P/Cr by the eCER equations. The average bias of the ePER formulas adjusted by the Cockcroft-Gault, Ghazali-Barratt, and Hellerstein equations were -0.067, 0.031, and 0.064 g/day, respectively, whereas the average bias of Spot P/Cr was -0.270 g/day obtained by the Bland-Altman graphics. Conclusion: Using equations to estimate eCER may improve the accuracy and reduce the spot urine samples' bias in pediatric kidney transplantation recipients. Further studies in larger populations are needed for ePER reporting to be ready for clinical practice.en_US
dc.identifier.citationIncir, S., Tasdemir, M., Kocak, B., Yelken, B., Arpali, E., Akyollu, B., Palaoglu, K. E., Baygul, A., Bilge, I., & Turkmen, A. (2021). Improving the urine spot protein/creatinine ratio by the estimated creatinine excretion to predict proteinuria in pediatric kidney transplant recipients. Pediatric transplantation, e14142. Advance online publication.en_US
dc.identifier.doi10.1111/petr.14142en_US
dc.identifier.pmid34523202en_US
dc.identifier.scopus2-s2.0-85114799978en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1111/petr.14142
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2090
dc.identifier.wosWOS:000695718900001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTaşdemir, Mehmet
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofPediatric Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAccuracyen_US
dc.subjectCreatinine Excretion Rateen_US
dc.subjectProtein Excretion Rateen_US
dc.subjectProtein-to-creatinine Ratioen_US
dc.subjectProteinuriaen_US
dc.titleImproving the urine spot protein/creatinine ratio by the estimated creatinine excretion to predict proteinuria in pediatric kidney transplant recipientsen_US
dc.typeArticleen_US

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