Increased visinin-like protein-1, YKL-40, lipocalin-2, and IL-23 levels in patients with migraine

Basit Öğe Kaydı
dc.authorscopusidVugar Cafer / 57300542900en_US
dc.authorwosidVugar Cafer / EOM-5613-2022
dc.contributor.authorDündar, Ahmet
dc.contributor.authorCafer, Vugar
dc.contributor.authorAslanhan, Hamza
dc.contributor.authorÖzdemir, Hasan Hüseyin
dc.contributor.authorYılmaz , Ahmet
dc.contributor.authorÇevik, Mehmet Uğur
dc.date.accessioned2022-12-30T09:48:35Z
dc.date.available2022-12-30T09:48:35Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Hastaneen_US
dc.description.abstractBackground: Migraine is a type of primary headache caused by changes in the trigeminal system and has been reported to be associated with neurovascular inflammation of cerebral and extracerebral vessels. Objective: It is known that inflammation is an important process in the pathogenesis of migraine. It has been shown that the molecules of visinin-like protein 1 (Vilip-1), YKL-40, lipocalin-2 and interleukin (IL)-23 play a role in the inflammatory process. Our aim is to investigate the role of this molecule in the metabolic pathway of migraine disease. Methods: Fifty migraine patients with and without aura in the interictal period were included in the study. Vilip-1, YKL-40, lipocalin-2, and IL-23 levels were measured by ELISA method. Results: Serum vilip-1, YKL-40, lipocalin-2, and IL-23 levels were found to be significantly higher in migraine patients compared to the control group. We found that this molecule increased significantly in migraine subgroups compared to the control group (p < 0.001). A positive significant correlation was found between vilip-1 level and YKL-40 and lipocalin-2 levels in migraine patients. In addition, a positive correlation was observed between visual analogue scale score, number of days with pain and vilip-1 level (p < 0.01). The results of our study showed that activation of inflammatory mediators may play a role in the pathogenesis of migraine disease. In addition, our study is valuable in that inflammatory molecules are high in the interictal period and these biomarkers have never been analyzed in migraine patients. However, we still believe that larger studies are needed to explain the role of vilip-1, YKL-40, lipocalin-2, and IL-23 in the molecular mechanism of migraine disease.en_US
dc.identifier.citationDündar, A., Cafer, V., Aslanhan, H., Özdemir, H. H., Yilmaz, A., & Çevik, M. U. (2022). Increased visinin-like protein-1, YKL-40, lipocalin-2, and IL-23 levels in patients with migraine. Neurological research, 1–6. Advance online publication. https://doi.org/10.1080/01616412.2022.2156125en_US
dc.identifier.doi10.1080/01616412.2022.2156125en_US
dc.identifier.endpage6en_US
dc.identifier.pmid36526441en_US
dc.identifier.scopus2-s2.0-85144317539en_US
dc.identifier.startpage1en_US
dc.identifier.urihttp://dx.doi.org/10.1080/01616412.2022.2156125
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3800
dc.identifier.volume16en_US
dc.identifier.wosWOS:000898515400001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorCafer, Vugar
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofNeurological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectL-23en_US
dc.subjectMigraineen_US
dc.subjectYKL-40en_US
dc.subjectInflammationen_US
dc.subjectLipocalin-2en_US
dc.subjectVilip-1en_US
dc.titleIncreased visinin-like protein-1, YKL-40, lipocalin-2, and IL-23 levels in patients with migraineen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
Dundar-2022-Increased-visinin-like-protein--ykl (1).pdf
Boyut:
800.88 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

PubMed İndeksli Yayınlar Koleksiyonu
İSÜ Hastaneleri Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu