Targeting Nrf2 in ischemia-reperfusion alleviation: From signaling networks to therapeutic targeting

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dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100en_US
dc.authorwosidAli Zarrabi / U-2602-2019
dc.contributor.authorSadrkhanloo, Mehrdokht
dc.contributor.authorEntezari, Maliheh
dc.contributor.authorOrouei, Sima
dc.contributor.authorZabolian, Amirhossein
dc.contributor.authorMirzaie, Amirreza
dc.contributor.authorMaghsoudloo, Amin
dc.contributor.authorRaesi, Rasoul
dc.contributor.authorAsadi, Neda
dc.contributor.authorHashemi, Mehrdad
dc.contributor.authorZarrabi, Ali
dc.contributor.authorKhan, Haroon
dc.contributor.authorMirzaei, Sepideh
dc.contributor.authorSamarghandian, Saeed
dc.date.accessioned2022-05-20T11:27:51Z
dc.date.available2022-05-20T11:27:51Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractThe nuclear factor erythroid 2-related factor 2 (Nrf2) is a master regulator of redox balance and it responds to various cell stresses that oxidative stress is the most well-known one. The Nrf2 should undergo nuclear translocation to exert its protective impacts and decrease ROS production. On the other hand, ischemic/reperfusion (I/R) injury is a pathological event resulting from low blood flow to an organ and followed by reperfusion. The I/R induces cell injury and organ dysfunction. The present review focuses on Nrf2 function in alleviation of I/R injury. Stimulating of Nrf2 signaling ameliorates I/R injury in various organs including lung, liver, brain, testis and heart. The Nrf2 enhances activity of antioxidant enzymes to reduce ROS production and prevent oxidative stress-mediated cell death. Besides, Nrf2 reduces inflammation via decreasing levels of pro-inflammatory factors including IL-6, IL-1? and TNF-?. Nrf2 signaling is beneficial in preventing apoptosis and increasing cell viability. Nrf2 induces autophagy to prevent apoptosis during I/R injury. Furthermore, it can interact with other molecular pathways including PI3K/Akt, NF-?B, miRNAs, lncRNAs and GSK-3? among others, to ameliorate I/R injury. The therapeutic agents, most of them are phytochemicals such as resveratrol, berberine and curcumin, induce Nrf2 signaling in I/R injury alleviation. © 2022en_US
dc.identifier.citationSadrkhanloo, M., Entezari, M., Orouei, S., Zabolian, A., Mirzaie, A., Maghsoudloo, A., . . . Samarghandian, S. (2022). Targeting Nrf2 in ischemia-reperfusion alleviation: From signaling networks to therapeutic targeting. Life Sciences, 300 doi:10.1016/j.lfs.2022.120561en_US
dc.identifier.doi10.1016/j.lfs.2022.120561en_US
dc.identifier.scopus2-s2.0-85129262781en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1016/j.lfs.2022.120561
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2685
dc.identifier.volume300en_US
dc.identifier.wosWOS:000808284600002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherElsevier Inc.en_US
dc.relation.ispartofLife Sciencesen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidanten_US
dc.subjectIschemicen_US
dc.subjectOxidative Stressen_US
dc.subjectPlant Derived-Natural Compoundsen_US
dc.subjectTherapeutic Targetingen_US
dc.titleTargeting Nrf2 in ischemia-reperfusion alleviation: From signaling networks to therapeutic targetingen_US
dc.typeReview Articleen_US

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