Endothelium-derived microparticles are increased in teenagers with cobalamin deficiency

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dc.authoridYasemin Altuner Torun / 0000-0002-9860-8596en_US
dc.authorscopusidYasemin Altuner Torun / 56615130500
dc.contributor.authorDündar, Mehmet Akif
dc.contributor.authorAltuner Torun, Yasemin
dc.contributor.authorÇetin, Feyza
dc.contributor.authorOz, Hatice T.
dc.date.accessioned2021-08-19T06:43:18Z
dc.date.available2021-08-19T06:43:18Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroduction: Vitamin B12 (cobalamin) deficiency may be a significant cause of hyperhomocysteinemia, and high homocysteine (Hcy) levels are associated with an increased risk of cardiovascular disease. Endothelium-derived microparticles (EMPs) are a new marker in endothelial dysfunction and atherosclerosis, which play a role in cardiovascular diseases’ pathogenesis. This study aimed to evaluate the EMPs, the markers of endothelial dysfunction and atherosclerosis, and lipid profile in teenagers with cobalamin deficiency. Materials and Methods: This prospective study included 143 teenagers, 75 vitamin B12 deficient patients and 68 healthy controls between 11 and 18 years of age. Routine laboratory tests, hemogram, vitamin B12, folic acid, ferritin, Hcy, lipid profile and EMPs were examined and compared. EMP subgroups were analyzed by flow cytometry method according to the expression of membranespecific antigens. The microparticles released from the endothelium studied were VE-cadherin (CD144), S-endo1 (CD146), and Endoglin (CD105). Results: The present study demonstrates that circulating CD105+ EMP, CD144+ EMP, CD146+ EMPs, and Hcy were increased, and high-density lipoprotein (HDL) cholesterol was reduced in teenagers with cobalamin deficiency. Vitamin B12 showed a negative correlation with EMPs and Hcy, positive correlation with folate and HDL. All EMPs showed a significant positive correlation with triglyceride, vitamin B12, and HDL. Conclusion: Vitamin B12 deficiency may predispose to endothelial damage and atherosclerosis by increasing EMPs and harms lipid metabolism in the long term.en_US
dc.identifier.citationDundar, M. A., Torun, Y. A., Cetin, F., & Oz, H. T. (2021). Endothelium-derived Microparticles Are Increased in Teenagers With Cobalamin Deficiency. Journal of pediatric hematology/oncology, 10.1097/MPH.0000000000002286. Advance online publication. https://doi.org/10.1097/MPH.0000000000002286en_US
dc.identifier.doi10.1097/MPH.0000000000002286en_US
dc.identifier.pmid34387625en_US
dc.identifier.scopus2-s2.0-85112862216en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1097/MPH.0000000000002286
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2008
dc.identifier.wosWOS:000830653000013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAltuner Torun, Yasemin
dc.language.isoenen_US
dc.publisherWolters Kluwer Healthen_US
dc.relation.ispartofJ Pediatr Hematol Oncol.en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAtherosclerosisen_US
dc.subjectChilden_US
dc.subjectEndothelial Microparticlesen_US
dc.subjectTeenagersen_US
dc.subjectCobalamin Deficiencyen_US
dc.titleEndothelium-derived microparticles are increased in teenagers with cobalamin deficiencyen_US
dc.typeArticleen_US

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