The effect of thiol functional groups on bovine serum albumin/chitosan buccal mucoadhesive patches

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dc.authoridAyça Bal Öztürk / 0000-0002-6502-528Xen_US
dc.authoridGülşah Torkay / 0000-0002-6803-494X
dc.authorscopusidAyça Bal Öztürk / 57062000100en_US
dc.authorscopusidGülşah Torkay / 57753937500
dc.authorwosidAyça Bal Öztürk / M-4472-2018en_US
dc.authorwosidGülşah Torkay / IUP-3797-2023
dc.contributor.authorBal Öztürk, Ayça
dc.contributor.authorAlarçin, Emine
dc.contributor.authorÖzbaş, Zehra
dc.contributor.authorÖzkahraman, Bengi
dc.contributor.authorTorkay, Gülşah
dc.date.accessioned2022-07-05T14:07:02Z
dc.date.available2022-07-05T14:07:02Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Temel Bilimleri Bölümüen_US
dc.description.abstractIn this research, the effect of thiol functional groups on bovine serum albumin (BSA)/chitosan (Chi) based buccal mucoadhesive patch was investigated. Thiolated BSA (BSA-SH) was prepared via 2-mercaptoethanol. FTIR and 1H NMR results confirmed that BSA-SH was synthesized successfully. The buccal mucoadhesive patches were fabricated by the solvent casting method. Following the structural characterization of BSA/Chi and BSA-SH/Chi buccal patches, the mechanical characterization was performed by tensile tests. The drug release from triam- cinolone acetonide (TR) loaded buccal patches was evaluated in-vitro in simulated salivary. According to the ex- vivo buccal adhesion experiments, the mechanical and mucoadhesion properties of BSA-SH/Chi buccal patch had improved compared to BSA/Chi buccal patch. The total cumulative TR permeated after 12 h was higher for BSA- SH/Chi than BSA/Chi buccal patches. The developed mucoadhesive buccal patches were found to be biocom- patible in vitro. To conclude, the thiolated BSA-SH/Chi buccal adhesive patch is a promising biomaterial for a satisfied drug delivery, which provides advantages for various oral applications.en_US
dc.identifier.citationBal-Öztürk, A., Torkay, G., Alarçin, E., Özbaş, Z., & Özkahraman, B. (2022). The effect of thiol functional groups on bovine serum albumin/chitosan buccal mucoadhesive patches. Journal of Drug Delivery Science and Technology, 74 doi:10.1016/j.jddst.2022.103493en_US
dc.identifier.doi10.1016/j.jddst.2022.103493en_US
dc.identifier.issn1773-2247en_US
dc.identifier.scopus2-s2.0-85132367698en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttp://doi.org/10.1016/j.jddst.2022.103493
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2962
dc.identifier.volume74en_US
dc.identifier.wosWOS:000835716100002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorBal Öztürk, Ayça
dc.language.isoenen_US
dc.publisherEditions de Santeen_US
dc.relation.ispartofJournal of Drug Delivery Science and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThiolated Bovine Serum Albuminen_US
dc.subjectChitosanen_US
dc.subjectBuccal Patchen_US
dc.subjectEx-Vivo Mucoadhesionen_US
dc.subjectTriamcinolone Acetonideen_US
dc.titleThe effect of thiol functional groups on bovine serum albumin/chitosan buccal mucoadhesive patchesen_US
dc.typeArticleen_US

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