Unveiling the molecular Culprit of arterial stiffness in vitamin D deficiency and obesity: Potential for novel therapeutic targets

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dc.authoridKhan, Naveed/0000-0001-7667-8553
dc.authoridSiddiqui, Ruqaiyyah/0000-0001-9646-6208
dc.authoridElmoselhi, Adel B/0000-0003-2152-6629
dc.authoridBajbouj, Khuloud/0000-0001-7344-6095
dc.authorwosidKhan, Naveed/AAM-2892-2021
dc.authorwosidKhan, Naveed/KCK-0156-2024
dc.authorwosidSiddiqui, Ruqaiyyah/AIF-2100-2022
dc.contributor.authorElmoselhi, Adel B.
dc.contributor.authorBouzid, Amal
dc.contributor.authorAllah, Mohamed Seif
dc.contributor.authorIbrahim, Zeinab
dc.contributor.authorBajbouj, Khuloud
dc.contributor.authorAssaleh, Rebal S. Abou
dc.contributor.authorVenkatachalam, Thenmozhi
dc.date.accessioned2024-05-19T14:50:21Z
dc.date.available2024-05-19T14:50:21Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractCardiovascular diseases (CVDs) are highly associated with both vitamin D deficiency and obesity, two prevalent health conditions worldwide. Arterial stiffness, an independent predictor of CVDs, is particularly elevated in both conditions, yet the molecular mechanisms underlying this phenomenon remain elusive, hindering effective management of CVDs in this population. We recruited 20 middle-aged Emiratis, including 9 individuals with vitamin D deficiency (Vit D level <= 20 ng) and obesity (BMI >= 30) and 11 individuals as control with Vit D level >20 ng and BMI <30. We measured arterial stiffness using pulse wave velocity (PWV) and performed whole transcriptome sequencing to identify differentially expressed genes (DEGs) and enriched pathways. We validated these findings using qRT-PCR, Western blot, and multiplex analysis. PWV was significantly higher in the vitamin D deficient and obese group relative to controls (p <= 0.05). The DEG analysis revealed that pathways related to interleukin 1 (IL-1), nitrogen metabolism, HIF-1 signaling, and MAPK signaling were over-activated in the vitamin D deficient and obese group. We found that HIF-1alpha, NOX-I, NOX-II, IL-1b, IL-8, IL-10, and VEGF were significantly upregulated in the vitamin D deficient and obese group (p < 0.05). Our study provides new insights into the molecular mechanisms of arterial stiffness in vitamin D deficiency and obesity, demonstrating the role of oxidative stress and inflammation in this process. Our findings suggest that these biomarkers may serve as potential therapeutic targets for early prevention of CVDs. Further studies are needed to investigate these pathways and biomarkers with larger cohort.en_US
dc.identifier.doi10.1016/j.heliyon.2023.e22067
dc.identifier.issn2405-8440
dc.identifier.issue11en_US
dc.identifier.pmid38027669en_US
dc.identifier.scopus2-s2.0-85176136622en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org10.1016/j.heliyon.2023.e22067
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5679
dc.identifier.volume9en_US
dc.identifier.wosWOS:001112958700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCell Pressen_US
dc.relation.ispartofHeliyonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectVitamin Den_US
dc.subjectObesityen_US
dc.subjectVascular Dysfunctionen_US
dc.subjectOxidative Stressen_US
dc.subjectInflammatory Markersen_US
dc.subjectNox Genesen_US
dc.titleUnveiling the molecular Culprit of arterial stiffness in vitamin D deficiency and obesity: Potential for novel therapeutic targetsen_US
dc.typeArticleen_US

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