Utility of estimated glucose disposal rate for predicting metabolic syndrome in children and adolescents with type-1 diabetes

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dc.contributor.authorKoken, Ozlem Yayici
dc.contributor.authorKara, Cengiz
dc.contributor.authorYilmaz, Gulay Can
dc.contributor.authorAydin, Hasan Murat
dc.date.accessioned2020-08-30T20:06:08Z
dc.date.available2020-08-30T20:06:08Z
dc.date.issued2020
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionPubMed: 32628635en_US
dc.descriptionKara, Cengiz (isu author)
dc.description.abstractObjectives: To determine the clinical utility of the estimated glucose disposal rate (eGDR) for predicting metabolic syndrome (MetS) in children and adolescents with type-1 diabetes (T1D). Methods: Modified criteria of the International Diabetes Federation were used to determine MetS in children and adolescents between 10 and 18 years of age with T1D. The eGDR, a validated marker of insulin sensitivity, was calculated in two different ways using either the waist-to-hip ratio (WHR) or waist circumference (WC). Receiver operating characteristic (ROC) curve analysis was performed to ascertain cut-off levels of the eGDR to predict MetS. Results: A total of 200 patients (52% male) with T1D were enrolled in the study. The prevalence of MetS was 10.5% (n: 21). Lower eGDR levels, indicating greater insulin resistance, were found in T1D patients with MetS when compared to those without (6.41 +/- 1.86 vs. 9.50 +/- 1.34 mg/kg/min) (p < 0.001). An eGDR(WHR) cut-off of 8.44 mg/kg/min showed 85.7% sensitivity and 82.6% specificity, while an eGDR(WC) cut-off of 8.16 mg/kg/min showed 76.1% sensitivity and 92.1% specificity for MetS diagnosis. The diagnostic odds ratio was 28.6 (7.3-131.0) for the eGDR(WHR) cut-off and 37.7 (10.8-140.8) for the eGDR(WC) cut-off. Conclusions: The eGDR is a mathematical formula that can be used in clinical practice to detect the existence of MetS in children and adolescents with T1D using only the WC, existence of hypertension, and hemoglobin A1c levels. An eGDR calculated using the WC could be a preferred choice due to its higher diagnostic performance.en_US
dc.identifier.citationKoken, O. Y., Kara, C., Yilmaz, G. C., & Aydin, H. M. (2020). Utility of estimated glucose disposal rate for predicting metabolic syndrome in children and adolescents with type-1 diabetes. JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, 33(7), 859–864. https://doi.org/10.1515/jpem-2020-0012en_US
dc.identifier.doi10.1515/jpem-2020-0012en_US
dc.identifier.endpage864en_US
dc.identifier.issn0334-018Xen_US
dc.identifier.issn2191-0251en_US
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-85088496340en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage859en_US
dc.identifier.urihttps://doi.org/10.1515/jpem-2020-0012
dc.identifier.urihttps://hdl.handle.net/20.500.12713/375
dc.identifier.volume33en_US
dc.identifier.wosWOS:000552012000005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKara, Cengizen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofJournal of Pediatric Endocrinology & Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDouble Diabetesen_US
dc.subjectMetabolic Syndromeen_US
dc.subjectType-1 Diabetesen_US
dc.titleUtility of estimated glucose disposal rate for predicting metabolic syndrome in children and adolescents with type-1 diabetesen_US
dc.typeArticleen_US

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