Nanocarrier Drug Conjugates Exhibit Potent Anti-Naegleria fowleri and Anti-Balamuthia mandrillaris Properties

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dc.authoridKhan, Naveed/0000-0001-7667-8553
dc.authoridSiddiqui, Ruqaiyyah/0000-0001-9646-6208
dc.authoridShahrul Anuar, Tengku/0000-0001-6860-495X
dc.authoridShah, Muhammad Raza/0000-0003-4978-3627
dc.authoridJabri, tooba/0000-0001-5889-0913
dc.authoridMohamed Mohamed Abdoh AL Shareef, Zainab/0000-0003-4213-1052
dc.authorwosidShah, Muhammad Raza/AAR-3981-2021
dc.authorwosidKhan, Naveed/AAM-2892-2021
dc.authorwosidKhan, Naveed/KCK-0156-2024
dc.authorwosidSiddiqui, Ruqaiyyah/AIF-2100-2022
dc.authorwosidShahrul Anuar, Tengku/JDV-9939-2023
dc.contributor.authorSiddiqui, Ruqaiyyah
dc.contributor.authorBoghossian, Anania
dc.contributor.authorKawish, Muhammad
dc.contributor.authorJabri, Tooba
dc.contributor.authorShah, Muhammad Raza
dc.contributor.authorAnuar, Tengku Shahrul
dc.contributor.authorAl-Shareef, Zainab
dc.date.accessioned2024-05-19T14:45:55Z
dc.date.available2024-05-19T14:45:55Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractGiven the opportunity and access, pathogenic protists (Balamuthia mandrillaris and Naegleria fowleri) can produce fatal infections involving the central nervous system. In the absence of effective treatments, there is a need to either develop new antimicrobials or enhance the efficacy of existing compounds. Nanocarriers as drug delivery systems are gaining increasing attention in the treatment of parasitic infections. In this study, novel nanocarriers conjugated with amphotericin B and curcumin were evaluated for anti-amoebic efficacy against B. mandrillaris and N. fowleri. The results showed that nanocarrier conjugated amphotericin B exhibited enhanced cidal properties against both amoebae tested compared with the drug alone. Similarly, nanocarrier conjugated curcumin exhibited up to 75% cidal effects versus approx. 50% cidal effects for curcumin alone. Cytopathogenicity assays revealed that the pre-treatment of both parasites with nanoformulated-drugs reduced parasite-mediated host cellular death compared with the drugs alone. Importantly, the cytotoxic effects of amphotericin B on human cells alone were reduced when conjugated with nanocarriers. These are promising findings and further suggest the need to explore nanocarriers as a means to deliver medicine against parasitic infections.en_US
dc.identifier.doi10.3390/diseases11020058
dc.identifier.issn2079-9721
dc.identifier.issue2en_US
dc.identifier.pmid37092440en_US
dc.identifier.scopus2-s2.0-85163753609en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org10.3390/diseases11020058
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5394
dc.identifier.volume11en_US
dc.identifier.wosWOS:001014263600001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofDiseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectNaegleria Fowlerien_US
dc.subjectBalamuthia Mandrillarisen_US
dc.subjectCurcuminen_US
dc.subjectNanoparticleen_US
dc.subjectAnti-Amoebicen_US
dc.subjectFatalen_US
dc.subjectBlood Brain Barrieren_US
dc.titleNanocarrier Drug Conjugates Exhibit Potent Anti-Naegleria fowleri and Anti-Balamuthia mandrillaris Propertiesen_US
dc.typeArticleen_US

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