The relationship between plexin C1 overexpression and survival in hepatocellular carcinoma: a Turkish oncology group (TOG) study

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dc.authoridLevent Korkmaz / 0000-0001-6931-6896en_US
dc.authorscopusidLevent Korkmaz / 57188703248
dc.authorwosidLevent Korkmaz / AGF-5971-2022
dc.contributor.authorTurhal, Serdar Nazım
dc.contributor.authorDoğan, Mutlu
dc.contributor.authorEsendağlı, Güldal
dc.contributor.authorArtaç, Mehmet
dc.contributor.authorKorkmaz, Levent
dc.contributor.authorÇoşkun, Hasan Şenol
dc.contributor.authorGöker, Erdem
dc.date.accessioned2021-03-05T10:10:56Z
dc.date.available2021-03-05T10:10:56Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Bilgisayar Mühendisliği Bölümüen_US
dc.description.abstractPurpose Plexin C1 is a transmembrane receptor and plexin C1 overexpression might have role in carcinogenesis. Hepatocellular carcinoma (HCC) has poor prognosis because of its aggressive behavior and limited treatment options, especially in advanced stage. We recently documented that Plexin C1 was overexpressed in HCC. We aimed to evaluate the prognostic signifcance of Plexin C1 overexpression in HCC in the present study. Methods Plexin C1 overexpression was evaluated immunohistochemically on parafn-embedded blocks of the HCC patients. Plexin C1 immunohistochemical staining was scored. Plexin C1 overexpression staining intensity and prevalence were used for plexin scale staining evaluation and plexin scores were estimated according this staining scale. Plexin C1 score and its association with survival and clinicopathological features was assessed. Results Sixty-seven HCC patients with adequate tissue for pathological evaluation were included. Median age was 63 years with male predominance (male to female ratio was 4.75 (n 57/12). Well-diferentiated HCC (53.7%) patients had higher plexin C1 overexpression (p<0.05). Median OS was 22.1 months. Patients with lower plexin C1 score (<12) had shorter OS (17.5 vs 30.1 months, p=0.036). Neutrophil count, GGT, and PNR (platelet/neutrophil ratio) had prognostic signifcance (p=0.047, p=0.018, and p=0.045). Conclusion Plexin C1 overexpression is inversely correlated with grade in HCC. The patients with lower rate of Plexin C1 overexpression have worse survival outcome. It might be a prognostic factor in HCC.en_US
dc.identifier.citationNazimTurhal, S., Dogan, M., Esendagli, G., Artac, M., Korkmaz, L., Coskun, H. S., Goker, E., PerranYumuk, F., Bilgetekin, I., Kose, F., Uncu, D., Kavgaci, H., Akyol, G., Ozet, A., & Yagci, T. (2021). The Relationship Between Plexin C1 Overexpression and Survival in Hepatocellular Carcinoma: a Turkish Oncology Group (TOG) Study. Journal of gastrointestinal cancer, 10.1007/s12029-021-00602-4. Advance online publication. https://doi.org/10.1007/s12029-021-00602-4en_US
dc.identifier.doi10.1007/s12029-021-00602-4en_US
dc.identifier.issue1en_US
dc.identifier.pmid33656690en_US
dc.identifier.scopus2-s2.0-85131347050en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1007/s12029-021-00602-4
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1515
dc.identifier.volume52en_US
dc.identifier.wosWOS:000625053000002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKorkmaz, Levent
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Gastrointestinal Canceren_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHepatocellular Carcinomaen_US
dc.subjectHccen_US
dc.subjectPlexinen_US
dc.titleThe relationship between plexin C1 overexpression and survival in hepatocellular carcinoma: a Turkish oncology group (TOG) studyen_US
dc.typeArticleen_US

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