The view of Turkish oncologists regarding MSI status and tumor localization in stage II and III colon cancer

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dc.authoridNuri Faruk Aykan / 0000-0002-5472-3218
dc.authorscopusidNuri Faruk Aykan / 57219836263
dc.authorwosidNuri Faruk Ayhan / I-6425-2019
dc.contributor.authorBeypınar, İsmail
dc.contributor.authorDemir, Hacer
dc.contributor.authorAraz, Murat
dc.contributor.authorBaykara, Meltem
dc.contributor.authorAykan, Nuri Faruk
dc.date.accessioned2020-11-09T07:46:23Z
dc.date.available2020-11-09T07:46:23Z
dc.date.issued2020en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroduction: Although several clinical factors which show the benefit of adjuvant chemotherapy (AC) in early-stage colon cancer use for evaluating the risk of relapse, there is no consensus on which risk factors are more reliable. In this study, we evaluated both the utility of MSI and the daily practice of the Turkish oncologists in stage II and III colon cancer. Material and method: We conducted an online questionnaire which was consisting of twenty questions including the treatment choices and duration about stage II-III colon cancer depending on sidedness and risk factors for relapse. Results: More than 65% of the oncologists declared the use of MSI testing in stage II colon cancer without considering any risk factors. In stage 3 colon cancer oncologists had an equal decision "to do or not to do" in MSI testing. More than 50% of the oncologists had preferred XELOX protocol in high-risk stage II (T4N0) colon cancer, while three out of four preferred observation in low-risk stage II (T3N0) patients without risk factors. Two-thirds of the oncologists had preferred 6 months of treatment in stage II colon cancer with at least one risk factor. Conclusion: Turkish oncologists participating to this trial had declared conflicting results about adjuvant treatment in early-stage colorectal cancer in their daily practice compared with the updated guidelines, especially, MSI evaluation utility in stage III colon cancers, adjuvant chemotherapy (AC) duration, and oxaliplatin adding to AC in elderly and stage II patients.en_US
dc.identifier.citationBeypinar, I., Demir, H., Araz, M., Baykara, M., & Aykan, N. F. (2020). The View of Turkish Oncologists Regarding MSI Status and Tumor Localization in Stage II and III Colon Cancer. Journal of gastrointestinal cancer, 10.1007/s12029-020-00542-5. Advance online publication. https://doi.org/10.1007/s12029-020-00542-5en_US
dc.identifier.doi10.1007/s12029-020-00542-5en_US
dc.identifier.pmid33159235en_US
dc.identifier.scopus2-s2.0-85095697945en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1007/s12029-020-00542-5
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1184
dc.identifier.wosWOS:000587097600001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAykan, Nuri Faruk
dc.language.isoenen_US
dc.relation.ispartofJournal of gastrointestinal canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdjuvant Treatmenten_US
dc.subjectColon Canceren_US
dc.subjectDuration of Treatmenten_US
dc.subjectMSI Testingen_US
dc.subjectMicrosatellite Instabilityen_US
dc.titleThe view of Turkish oncologists regarding MSI status and tumor localization in stage II and III colon canceren_US
dc.typeArticleen_US

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