Palladium(II) and platinum(II) saccharinate complexes with bis(diphenylphosphino)methane/ethane: synthesis, S-phase arrest and ROS-mediated apoptosis in human colon cancer cells

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dc.authoridEngin Ulukaya / 0000-0003-4875-5472en_US
dc.authoridPınar Alper / 0000-0001-9631-3551en_US
dc.authorscopusidEngin Ulukaya / 6602927353
dc.authorscopusidAlper Pınar / 8912315800
dc.authorwosidEngin Ulukaya / K-5792-2018
dc.authorwosidPınar Alper / DUL-1586-2022
dc.contributor.authorİçsel, Ceyda
dc.contributor.authorYılmaz, Veysel T.
dc.contributor.authorAygün, Muhittin
dc.contributor.authorCevatemre, Buse
dc.contributor.authorAlper, Pınar
dc.contributor.authorUlukaya, Engin
dc.date.accessioned2020-08-30T20:07:21Z
dc.date.available2020-08-30T20:07:21Z
dc.date.issued2018
dc.departmentİstinye Üniversitesi, Rektörlüken_US
dc.description.abstractNew neutral [M(sac)(2)(diphos)] and cationic [M(diphos)(2)](sac)(2) complexes, where M = Pd-II or Pt-II, sac = saccharinate, and diphos = 1,1-bis(diphenylphosphino)methane (dppm) or 1,2-bis(diphenylphosphino)ethane (dppe), were synthesized and structurally characterized. The anticancer activity of the complexes was investigated against MCF-7 (breast), A549 (lung), HCT116 (colon), DU145 (prostate) cancer and BEAS-2B (normal bronchial epithelial) cells. Neutral Pt-dppm (2) and Pd-dppe complexes (5) did not show any biological activity. The cationic Pd-dppe (7) complex displayed antiproliferative activity, while the rest of the complexes exhibited potent cytotoxicity compared with cisplatin. The active Pd(ii)/Pt(ii) complexes were then included in further studies including interaction with DNA/HSA, nuclease activity, cellular uptake and lipophilicity. The potent complexes induced the apoptotic cell death as probed through annexin V positivity and caspase activation. Mechanistic studies on HCT116 cells showed that the complexes cause cell cycle arrest at the DNA synthesis (S) phase and excessive generation of reactive oxygen species (ROS), damaging to both mitochondria and DNA.en_US
dc.description.sponsorshipTUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [215Z230]en_US
dc.description.sponsorshipThe authors are grateful for the financial support provided by TUBITAK (Project no: 215Z230).en_US
dc.identifier.citationIcsel, C., Yilmaz, V. T., Aygun, M., Cevatemre, B., Alper, P., & Ulukaya, E. (2018). Palladium(ii) and platinum(ii) saccharinate complexes with bis(diphenylphosphino)methane/ethane: Synthesis, S-phase arrest and ROS-mediated apoptosis in human colon cancer cells. Dalton Transactions, 47(33), 11397–11410. https://doi.org/10.1039/c8dt02389aen_US
dc.identifier.doi10.1039/c8dt02389aen_US
dc.identifier.endpage11410en_US
dc.identifier.issn1477-9226en_US
dc.identifier.issn1477-9234en_US
dc.identifier.issue33en_US
dc.identifier.pmid30062356en_US
dc.identifier.scopus2-s2.0-85052000363en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage11397en_US
dc.identifier.urihttps://doi.org/10.1039/c8dt02389a
dc.identifier.urihttps://hdl.handle.net/20.500.12713/747
dc.identifier.volume47en_US
dc.identifier.wosWOS:000442509700014en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorAlper, Pınaren_US
dc.institutionauthorUlukaya, Enginen_US
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofDalton Transactionsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titlePalladium(II) and platinum(II) saccharinate complexes with bis(diphenylphosphino)methane/ethane: synthesis, S-phase arrest and ROS-mediated apoptosis in human colon cancer cellsen_US
dc.typeArticleen_US

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