Label-free surface enhanced raman spectroscopy for cancer detection

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dc.authoridMehmet Eser / 0000-0001-5227-1388en_US
dc.authorscopusidMehmet Eser / 6603121363en_US
dc.authorwosidMehmet Eser / DVL-0240-2022en_US
dc.contributor.authorAvcı, Ertuğ
dc.contributor.authorYılmaz, Hülya
dc.contributor.authorŞahiner, Nurettin
dc.contributor.authorTuna, Bilge Güvenç
dc.contributor.authorÇiçekdal, Münevver Burcu
dc.contributor.authorEser, Mehmet
dc.contributor.authorBaşak, Kayhan
dc.contributor.authorAltıntoprak, Fatih
dc.contributor.authorZengin, İsmail
dc.contributor.authorDoğan, Soner
dc.contributor.authorÇulha, Mustafa
dc.date.accessioned2022-11-13T18:35:04Z
dc.date.available2022-11-13T18:35:04Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractSimple Summary Blood is considered a rich reservoir of biomarkers for disease diagnosis. Surface-enhanced Raman scattering (SERS) is known for its high sensitivity and has been successfully employed to differentiate blood samples from cancer patients versus healthy individuals. Different from previous reports, this study aims at investigating the reliability of the observed results by varying several parameters influencing the observed spectra. Thus, blood taken from 30 healthy individuals as the control group, 30 patients with different types of cancers, and 15 patients with various types of chronic diseases were used in the study. The results revealed that spectral differences in the cancer group was directly related to the presence of cancer-related biomarkers. Although data were obtained from only small group of patients, the recorded sensitivity and specificity values clearly show the power of the technique to detect cancer. Blood is a vital reservoir housing numerous disease-related metabolites and cellular components. Thus, it is also of interest for cancer diagnosis. Surface-enhanced Raman spectroscopy (SERS) is widely used for molecular detection due to its very high sensitivity and multiplexing properties. Its real potential for cancer diagnosis is not yet clear. In this study, using silver nanoparticles (AgNPs) as substrates, a number of experimental parameters and scenarios were tested to disclose the potential for this technique for cancer diagnosis. The discrimination of serum samples from cancer patients, healthy individuals and patients with chronic diseases was successfully demonstrated with over 90% diagnostic accuracies. Moreover, the SERS spectra of the blood serum samples obtained from cancer patients before and after tumor removal were compared. It was found that the spectral pattern for serum from cancer patients evolved into the spectral pattern observed with serum from healthy individuals after the removal of tumors. The data strongly suggests that the technique has a tremendous potential for cancer detection and screening bringing the possibility of early detection onto the table.en_US
dc.identifier.citationAvci, E., Yilmaz, H., Sahiner, N., Tuna, B. G., Cicekdal, M. B., Eser, M., ... & Çulha, M. (2022). Label-Free Surface Enhanced Raman Spectroscopy for Cancer Detection. Cancers, 14(20), 5021.en_US
dc.identifier.doi10.3390/cancers14205021en_US
dc.identifier.issue20en_US
dc.identifier.scopus2-s2.0-85140632743en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.3390/cancers14205021
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3360
dc.identifier.volume14en_US
dc.identifier.wosWOS:000872620700001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorEser, Mehmet
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofCANCERSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSERSen_US
dc.subjectSilver Nanoparticlesen_US
dc.subjectCancer Detectionen_US
dc.subjectBlooden_US
dc.subjectHuman Serumen_US
dc.subjectPlasmaen_US
dc.titleLabel-free surface enhanced raman spectroscopy for cancer detectionen_US
dc.typeArticleen_US

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