Investigation of irisin?s role in pubertal onset physiology in female rats

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dc.authoridKocyigit, Abdurrahim/0000-0003-2335-412X
dc.authorwosidTorun, Emel Dikbas/AAI-4028-2021
dc.authorwosidKocyigit, Abdurrahim/P-8685-2019
dc.contributor.authorKutlu, Esra
dc.contributor.authorOzgen, Lker Tolga
dc.contributor.authorBulut, Huri
dc.contributor.authorKocyigit, Abdurrahim
dc.contributor.authorUstunova, Savas
dc.contributor.authorHuseyinbas, Onder
dc.contributor.authorTorun, Emel
dc.date.accessioned2024-05-19T14:46:21Z
dc.date.available2024-05-19T14:46:21Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractObjective: The timing of pubertal development is closely related to metabolic status and energy reserves. It is thought that irisin, which is involved in the regulation of energy metabolism and is shown to be present in the hypothalamo-pituitary-gonadal (HPG) axis, may play a role in this process. In our study, we aimed to investigate the effect of irisin administration on pubertal development and HPG axis in rats. Design-methods: 36 female rats were included in the study were divided into 3 groups: 100 ng/kg/day irisin treatment group (irisin-100), 50 ng/kg/day irisin treatment group (irisin-50), and control group. On the 38th day, serum samples were taken to determine levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH), estradiol and irisin. Brain hypothalamus samples were taken to determine levels of pulsatile gonadotropin-releasing hormone (GnRH), kisspeptin, neurokinin-B, dynorphin (Dyn), and makorin ring finger protein-3 (MKRN3).Results: Vaginal opening and estrus were seen firstly in the irisin-100 group. At the end of the study, the highest rate of vaginal patency was found in the irisin-100 group. Hypothalamic protein expression levels of GnRH, NKB and Kiss1 in homogenates; serum FSH, LH, and estradiol levels were the highest in the irisin-100 group, followed by the irisin-50 and control groups, respectively. Ovarian sizes were significantly greater in the irisin-100 group compared to the other groups. The hypothalamic protein expression levels of MKRN3 and Dyn were the lowest in the irisin-100 group.Conclusions: In this experimental study, irisin triggered the onset of puberty in a dose-dependent manner. Irisin administration caused the excitatory system to dominate in the hypothalamic GnRH pulse generator.en_US
dc.description.sponsorshipBezmialem Vakif University Scientific Research Projects Foundation [12.2017/36]en_US
dc.description.sponsorshipFunding This study is supported by Bezmialem Vakif University Scientific Research Projects Foundation (Project number: 12.2017/36) .en_US
dc.identifier.doi10.1016/j.peptides.2023.170976
dc.identifier.issn0196-9781
dc.identifier.issn1873-5169
dc.identifier.pmid36796677en_US
dc.identifier.scopus2-s2.0-85149301556en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org10.1016/j.peptides.2023.170976
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5503
dc.identifier.volume163en_US
dc.identifier.wosWOS:000949481400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofPeptidesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectPubertyen_US
dc.subjectHpg Axisen_US
dc.subjectI ? Risinen_US
dc.subjectGnrhen_US
dc.subjectKndyen_US
dc.titleInvestigation of irisin?s role in pubertal onset physiology in female ratsen_US
dc.typeArticleen_US

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