Individualized High Dose Intravenous Anakinra Treatment in Cancer Patients with COVID-19 Associated Cytokine Storm: A Retrospective Controlled Study
Küçük Resim Yok
Tarih
2024
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Doc Design Informatics Co Ltd
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Patients with COVID-19 accompanying cancer have been reported to have higher morbidity and mortality. In this study, we aimed to evaluate the high -dose high intravenous anakinra treatment response and outcome in patients with COVID-19-associated cytokine storm accompanying cancer. Methods: This retrospective observational study was carried out at a tertiary referral center between September 01, 2021, and February 01, 2022, in Turkey. The study population consisted of two groups: patients receiving high -dose intravenous anakinra and patients treated with standard care. Results: Data from 146 patients in the anakinra group and 114 patients in the control group were analyzed. Malignancy frequency was 11% (n=16) in the anakinra group and 7% (n=8) in the control group. In survival analysis, a significantly lower survival rate was observed in patients with malignancy than those without in the control group (log -rank: p=0.002) and patients with malignancy in the control group compared to the anakinra group (log -rank: p=0.013). However, it did not differ between patients with and without malignancy in the anakinra group (log -rank: p=0.9). Conclusion: In the control group, mortality was higher in patients with malignancy compared to those without malignancy, but not in the anakinra group. Also, mortality was higher in patients receiving SoC compared to anakinra. Intravenous high -dose anakinra treatment is safe and effective in patients with COVID-19 accompanying cancer.
Açıklama
Anahtar Kelimeler
Covid-19, Cancer, Cytokine Storm, Hyperinflammation, Anakinra
Kaynak
Infectious Diseases and Clinical Microbiology
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
6
Sayı
1
