The impact of continuous and intermittent ketogenic diets on cognitive behavior, motor function, and blood lipids in TgF344-AD rats

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dc.contributor.authorRutkowsky, J.M.
dc.contributor.authorRoland, Z.
dc.contributor.authorValenzuela, A.
dc.contributor.authorNguyen, A.B.
dc.contributor.authorPark, H.H.
dc.contributor.authorSix, N.
dc.contributor.authorDursun I.
dc.date.accessioned2024-05-19T14:33:18Z
dc.date.available2024-05-19T14:33:18Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractStudies suggest that ketogenic diets (KD) may improve memory in mouse models of aging and Alzheimer’s disease (AD). This study determined whether a continuous or intermittent KD (IKD) enhanced cognitive behavior in the TgF344-AD rat model of AD. At 6 months-old, TgF344-AD and wild-type (WT) littermates were placed on a control (CD), KD, or IKD (morning CD and afternoon KD) provided as two meals per day for 2 or 6 months. Cognitive and motor behavior and circulating ?-hydroxybutyrate (BHB), AD biomarkers and blood lipids were assessed. Animals on a KD diet had elevated circulating BHB, with IKD levels intermediate to CD and KD. TgF344-AD rats displayed impaired spatial learning memory in the Barnes maze at 8 and 12 months of age and impaired motor coordination at 12 months of age. Neither KD nor IKD improved performance compared to CD. At 12 months of age, TgF344-AD animals had elevated blood lipids. IKD reduced lipids to WT levels with KD further reducing cholesterol below WT levels. This study shows that at 8 or 12 months of age, KD or IKD intervention did not improve measures of cognitive or motor behavior in TgF344-AD rats; however, both IKD and KD positively impacted circulating lipids. © 2024 Rutkowsky et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.description.sponsorshipNational Institutes of Health, NIH: R21 AG064290; National Institutes of Health, NIH; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK: 2219-1059B192000996; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAKen_US
dc.description.sponsorshipThis work was funded by the National Institutes of Health (NIH R21 AG064290). Dr. Ilknur Dursun was supported by the Scientific and Technological Research Council of Turkey under the program TUBITAK 2219-International Postdoctoral Research Fellowship. (TUBITAK 2219-1059B192000996).en_US
dc.identifier.doi10.18632/aging.205741
dc.identifier.endpage5828en_US
dc.identifier.issn1945-4589
dc.identifier.issue7en_US
dc.identifier.pmid38613791en_US
dc.identifier.scopus2-s2.0-85190879339en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage5811en_US
dc.identifier.urihttps://doi.org/10.18632/aging.205741
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4180
dc.identifier.volume16en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherImpact Journals LLCen_US
dc.relation.ispartofAgingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectAlzheimer's Diseaseen_US
dc.subjectCognitive Behavioren_US
dc.subjectKetogenic Dieten_US
dc.subjectLipidsen_US
dc.subjectMotor Functionen_US
dc.titleThe impact of continuous and intermittent ketogenic diets on cognitive behavior, motor function, and blood lipids in TgF344-AD ratsen_US
dc.typeArticleen_US

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