Graphene oxide quantum dot-chitosan nanotheranostic platform as a pH-responsive carrier for improving curcumin uptake internalization: In vitro & in silico study

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dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100en_US
dc.authorwosidAli Zarrabi / U-2602-2019
dc.contributor.authorEsmaeili, Yasaman
dc.contributor.authorSeyedhosseini Ghaheh, Hooria
dc.contributor.authorGhasemi, Fahimeh
dc.contributor.authorShariati, Laleh
dc.contributor.authorRafienia, Mohammad
dc.contributor.authorBidram, Elham
dc.contributor.authorZarrabi, Ali
dc.date.accessioned2022-07-20T13:50:39Z
dc.date.available2022-07-20T13:50:39Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractWe herein fabricated a cancer nanotheranostics platform based on Graphene Oxide Quantum Dot-Chitosan-polyethylene glycol nanoconjugate (GOQD-CS-PEG), which were targeted with MUC-1 aptamer towards breast and colon tumors. The interaction between aptamer and MUC-1 receptor on the desired cells was investigated utilizing molecular docking. The process of curcumin release was investigated, as well as the potential of the produced nanocomposite in targeted drug delivery, specific detection, and photoluminescence imaging. The fluorescence intensity of GOQD-CS-PEG was reduced due to transferred energy between (cytosine-guanin) base pairs in the hairpin structure of the aptamer, resulting in an “on/off” photoluminescence bio-sensing. Interestingly, the integration of pH-responsive chitosan nanoparticles in the nanocomposite results in a smart nanocomposite capable of delivering more curcumin to desired tumor cells. When selectively binds to the MUC-1 receptor, the two strands of aptamer separate in acidic conditions, resulting in a sustained drug release and photoluminescence recovery. The cytotoxicity results also revealed that the nanocomposite was more toxic to MUC-1-overexpressed tumor cells than to negative control cell lines, confirming its selective targeting. As a result, the proposed nanocomposite could be used as an intelligent cancer nanotheranostic platform for tracing MUC-1-overexpressed tumor cells and targeting them with great efficiency and selectivity. © 2022 Elsevier B.V.en_US
dc.identifier.citationEsmaeili, Y., Seyedhosseini Ghaheh, H., Ghasemi, F., Shariati, L., Rafienia, M., Bidram, E., & Zarrabi, A. (2022). Graphene oxide quantum dot-chitosan nanotheranostic platform as a pH-responsive carrier for improving curcumin uptake internalization: In vitro & in silico study. Biomaterials Advances, 139 doi:10.1016/j.bioadv.2022.213017en_US
dc.identifier.doi10.1016/j.bioadv.2022.213017en_US
dc.identifier.issn2772-9508en_US
dc.identifier.scopus2-s2.0-85133883776en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1016/j.bioadv.2022.213017
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3025
dc.identifier.volume139en_US
dc.identifier.wosWOS:000834076400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofBiomaterials Advancesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnticancer Nanotheranosticsen_US
dc.subjectCurcumin Deliveryen_US
dc.subjectGraphene Oxide Quantum Dotsen_US
dc.subjectIn Silicoen_US
dc.subjectTargeted Therapyen_US
dc.subject“On/off” Photoluminescence Bio-Sensingen_US
dc.titleGraphene oxide quantum dot-chitosan nanotheranostic platform as a pH-responsive carrier for improving curcumin uptake internalization: In vitro & in silico studyen_US
dc.typeArticleen_US

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