Lipid-Based Delivery Systems for Flavonoids and Flavonolignans: Liposomes, Nanoemulsions, and Solid Lipid Nanoparticles

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dc.authoridSharifi, Fatemeh/0000-0003-1711-0540
dc.authoridZarepour, Atefeh/0000-0002-0347-5840
dc.authoridZarrabi, Ali/0000-0003-0391-1769
dc.authoridBeyzaei, Hamid/0000-0002-6824-1367
dc.authoridDehshahri, Ali/0000-0003-4458-1292
dc.authoridEmamjomeh, Abbasali/0000-0001-9438-329X
dc.authorwosidSharifi, Fatemeh/AAA-3666-2019
dc.authorwosidZarepour, Atefeh/AAH-9225-2020
dc.authorwosidZarrabi, Ali/U-2602-2019
dc.contributor.authorRanjbar, Shahla
dc.contributor.authorEmamjomeh, Abbasali
dc.contributor.authorSharifi, Fatemeh
dc.contributor.authorZarepour, Atefeh
dc.contributor.authorAghaabbasi, Kian
dc.contributor.authorDehshahri, Ali
dc.contributor.authorSepahvand, Azadeh Mohammadi
dc.date.accessioned2024-05-19T14:39:25Z
dc.date.available2024-05-19T14:39:25Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractHerbal chemicals with a long history in medicine have attracted a lot of attention. Flavonolignans and flavonoids are considered as two classes of the above-mentioned compounds with different functional groups which exhibit several therapeutic capabilities such as antimicrobial, anti-inflammatory, antioxidant, antidiabetic, and anticancer activities. Based on the studies, high hydrophobic properties of the aforementioned compounds limit their bioavailability inside the human body and restrict their wide application. Nanoscale formulations such as solid lipid nanoparticles, liposomes, and other types of lipid-based delivery systems have been introduced to overcome the above-mentioned challenges. This approach allows the aforementioned hydrophobic therapeutic compounds to be encapsulated between hydrophobic structures, resulting in improving their bioavailability. The above-mentioned enhanced delivery system improves delivery to the targeted sites and reduces the daily required dosage. Lowering the required daily dose improves the performance of the drug by diminishing its side effects on non-targeted tissues. The present study aims to highlight the recent improvements in implementing lipid-based nanocarriers to deliver flavonolignans and flavonoids.en_US
dc.description.sponsorshipUniversity of Zabol; [IR-UOZ-GR-2874]en_US
dc.description.sponsorshipAbbasali Emamjomeh received funding from & nbsp;University of Zabol (IR-UOZ-GR-2874).en_US
dc.identifier.doi10.3390/pharmaceutics15071944
dc.identifier.issn1999-4923
dc.identifier.issue7en_US
dc.identifier.pmid37514130en_US
dc.identifier.scopus2-s2.0-85166191717en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org10.3390/pharmaceutics15071944
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4774
dc.identifier.volume15en_US
dc.identifier.wosWOS:001071442900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofPharmaceuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectBioavailabilityen_US
dc.subjectLipid-Based Nanocarrieren_US
dc.subjectFlavonoidsen_US
dc.subjectFlavonolignansen_US
dc.subjectNanocarrieren_US
dc.titleLipid-Based Delivery Systems for Flavonoids and Flavonolignans: Liposomes, Nanoemulsions, and Solid Lipid Nanoparticlesen_US
dc.typeReview Articleen_US

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