Non-coding RNAs targeting notch signaling pathway in cancer : from proliferation to cancer therapy resistance

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dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100en_US
dc.authorwosidAli Zarrabi / U-2602-2019
dc.contributor.authorHashemi, Mehrdad
dc.contributor.authorHasani, Sahar
dc.contributor.authorHajimazdarany, Shima
dc.contributor.authorMirmazloomi, Seyed Reza
dc.contributor.authorMakvandy, Sara
dc.contributor.authorZabihi, Abbas
dc.contributor.authorGoldoost, Yeganeh
dc.contributor.authorGholinia, Nazanin
dc.contributor.authorKakavand, Amirabbas
dc.contributor.authorTavakolpournegari, Alireza
dc.contributor.authorSalimimoghadam, Shokooh
dc.contributor.authorNabavi, Noushin
dc.contributor.authorZarrabi, Ali
dc.contributor.authorTaheriazam, Afshin
dc.contributor.authorEntezari, Maliheh
dc.contributor.authorHushmandi, Kiavash
dc.date.accessioned2022-10-31T09:51:15Z
dc.date.available2022-10-31T09:51:15Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractCancer is a challenging to treat disease with a high mortality rate worldwide, nevertheless advances in science has led to a decrease in the number of death cases caused by cancer. Aberrant expression of genes occurs during tumorigenesis therefore targeting the signaling pathways that regulate these genes' expression is of importance in cancer therapy. Notch is one of the signaling pathways having interactions with other vital cell signaling molecules responsible for cellular functions such as proliferation, apoptosis, invasion, metastasis, epithelial-to-mesenchymal transition (EMT), angiogenesis, and immune evasion. Furthermore, the Notch pathway is involved in response to chemo- and radiotherapy. Thus, targeting the Notch signaling pathway in cancer therapy can be beneficial for overcoming the therapeutic gaps. Non-coding RNAs (ncRNAs) are a class of RNAs that include short ncRNAs (such as micro RNAs) and long ncRNAs (lncRNAs). MicroRNAs (miRNAs) are ~22 nucleotides in length while lncRNAs have more than 200 nucleotides. Both miRNAs and lncRNAs control vital cellular mechanisms in cells and affect various signaling pathways and Notch is among them. The current review aims to discuss the critical role of ncRNAs in the regulation of the Notch signaling pathway by focusing on different cancer hallmarks including proliferation, apoptosis, autophagy, EMT, invasion, metastasis, and resistance to therapies.en_US
dc.identifier.citationHashemi, M., Hasani, S., Hajimazdarany, S., Mirmazloomi, S. R., Makvandy, S., Zabihi, A., . . . Hushmandi, K. (2022). Non-coding RNAs targeting notch signaling pathway in cancer: From proliferation to cancer therapy resistance. International Journal of Biological Macromolecules, 222, 1151-1167. doi:10.1016/j.ijbiomac.2022.09.203en_US
dc.identifier.doi10.1016/j.ijbiomac.2022.09.203en_US
dc.identifier.endpage1167en_US
dc.identifier.scopus2-s2.0-85139298581en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1152en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2022.09.203
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3213
dc.identifier.volume222en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofInternational Journal of Biological Macromoleculesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCanceren_US
dc.subjectCancer Therapyen_US
dc.subjectlncRNAen_US
dc.subjectmiRNAen_US
dc.subjectNotchen_US
dc.titleNon-coding RNAs targeting notch signaling pathway in cancer : from proliferation to cancer therapy resistanceen_US
dc.typeArticleen_US

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