Natural products as a promising therapeutic strategy to target cancer stem cells

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dc.authoridÖykü Gönül Geyik / 0000-0003-3014-1253en_US
dc.authoridCaner Geyik / 0000-0002-8382-2186en_US
dc.authoridEngin Ulukaya / 0000-0003-4875-5472en_US
dc.authoridMerve Erkısa Genel / 0000-0002-3127-742X
dc.authoridMelda Sarıman / 0000-0003-0898-529X
dc.authorscopusidEngin Ulukaya / 6602927353
dc.authorscopusidMerve Erkısa Genel / 57126208900
dc.authorscopusidMelda Sarıman / 57191042731
dc.authorscopusidÖykü Gönül Geyik / 57221379876
dc.authorscopusidCaner Geyik / 36175828200
dc.authorwosidEngin Ulukaya / K-5792-2018
dc.authorwosidMerve Erkısa Genel / AAM-1001-2020
dc.authorwosidMelda Sarıman / ABB-8877-2021
dc.authorwosidÖykü Gönül Geyik / DYG-1749-2022
dc.authorwosidCaner Geyik / JAF-3309-2023
dc.contributor.authorErkısa Genel, Merve
dc.contributor.authorSarıman, Melda
dc.contributor.authorGönül Geyik, Öykü
dc.contributor.authorGeyik, Caner
dc.contributor.authorStanojkovic, Tatjana
dc.contributor.authorUlukaya, Engin
dc.date.accessioned2021-07-14T12:25:35Z
dc.date.available2021-07-14T12:25:35Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesien_US
dc.description.abstractCancer is still a deadly disease, and its treatment desperately needs to be managed in a very sophisticated way through fast-developing novel strategies. Most of the cancer cases eventually develop into recurrencies, for which cancer stem cells (CSCs) are thought to be responsible. They are considered as a subpopulation of all cancer cells of tumor tissue with aberrant regulation of self-renewal, unbalanced proliferation, and cell death properties. Moreover, CSCs show a serious degree of resistance to chemotherapy or radiotherapy and immune surveillance as well. Therefore, new classes of drugs are rushing into the market each year, which makes the cost of therapy increase dramatically. Natural products are also becoming a new research area as a diverse chemical library to suppress CSCs. Some of the products even show promise in this regard. So, the near future could witness the introduction of natural products as a source of new chemotherapy modalities, which may result in the development of novel anticancer drugs. They could also be a reasonably-priced alternative to highly expensive current treatments. Nowadays, considering the effects of natural compounds on targeting surface markers, signaling pathways, apoptosis, and escape from immunosurveillance have been a highly intriguing area in preclinical and clinical research. In this review, we present scientific advances regarding their potential use in the inhibition of CSCs and the mechanisms by which they kill the CSCs.en_US
dc.identifier.citationErkisa, M., Sariman, M., Geyik, O. G., Geyik, C., Stanojkovic, T., & Ulukaya, E. (2022). Natural Products as a Promising Therapeutic Strategy to Target Cancer Stem Cells. Current medicinal chemistry, 29(4), 741–783. https://doi.org/10.2174/0929867328666210628131409en_US
dc.identifier.doi10.2174/0929867328666210628131409en_US
dc.identifier.pmid34182899en_US
dc.identifier.scopus2-s2.0-85124874023en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.2174/0929867328666210628131409
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1922
dc.identifier.wosWOS:000754264900008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorErkısa Genel, Merve
dc.institutionauthorSarıman, Melda
dc.institutionauthorGönül Geyik, Öykü
dc.institutionauthorGeyik, Caner
dc.institutionauthorUlukaya, Engin
dc.language.isoenen_US
dc.relation.ispartofCurr Med Chem .en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCancer Stem Cellen_US
dc.subjectCancer Therapyen_US
dc.subjectCell Deathen_US
dc.subjectCell Signalingen_US
dc.subjectImmune Responsesen_US
dc.subjectNatural Productsen_US
dc.titleNatural products as a promising therapeutic strategy to target cancer stem cellsen_US
dc.typeArticleen_US

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