An Examination of the Effects of Propolis and Quercetin in a Rat Model of Streptozotocin-Induced Diabetic Peripheral Neuropathy

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dc.authoridDeniz, Mustafa/0000-0002-6888-0388
dc.authorwosidDeniz, Mustafa/ABF-1871-2020
dc.contributor.authorTueredi, Sibel
dc.contributor.authorCelik, Hakim
dc.contributor.authorDagli, Seyda Nur
dc.contributor.authorTaskin, Seyhan
dc.contributor.authorSeker, Ugur
dc.contributor.authorDeniz, Mustafa
dc.date.accessioned2024-05-19T14:40:48Z
dc.date.available2024-05-19T14:40:48Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractThe purpose of this study was to reveal the combined effects of propolis (P) and quercetin (Q) against diabetic peripheral neuropathy developing with streptozotocin-induced diabetes in rats. Sixty-four adult male rats were divided into eight equal groups: control, P (100 mg/kg/day), Q (100 mg/kg/day), P + Q (100 mg/day for both), diabetes mellitus (DM) (single-dose 60 mg/kg streptozotocin), DM + P, DM + Q, and DM + P + Q. The rats were sacrificed, and blood and sciatic nerve tissues were collected. Blood glucose and malondialdehyde (MDA) levels increased, while IL-6 and total antioxidant status decreased in the DM group (p = 0.016 and p = 0.047, respectively). Ultrastructural findings showed degeneration of the axon and myelin sheath. The apoptotic index (AI %), TNF-alpha, and IL-1 beta immunopositivity increased significantly in the DM group (p < 0.001). Morphological structures approaching those of the controls were observed in the DM + P, DM + Q, and DM + P + Q groups. Morphometric measurements increased markedly in all treatment groups (p < 0.001), while blood glucose and MDA levels, AI (%), TNF-alpha, and IL-1 beta immunopositivity decreased. In conclusion, the combined effects of propolis and quercetin in diabetic neuropathy may provide optimal morphological protection with neuroprotective effects by reducing hyperglycemia, and these may represent a key alternative supplement in regenerative medicine.en_US
dc.description.sponsorshipHarran University, BAPen_US
dc.description.sponsorshipNo Statement Availableen_US
dc.identifier.doi10.3390/cimb46030128
dc.identifier.endpage1974en_US
dc.identifier.issn1467-3037
dc.identifier.issn1467-3045
dc.identifier.issue3en_US
dc.identifier.pmid38534744en_US
dc.identifier.scopus2-s2.0-85188682757en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1955en_US
dc.identifier.urihttps://doi.org10.3390/cimb46030128
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5019
dc.identifier.volume46en_US
dc.identifier.wosWOS:001191950800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofCurrent Issues In Molecular Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectDiabetic Peripheral Neuropathyen_US
dc.subjectPropolisen_US
dc.subjectQuercetinen_US
dc.subjectRegenerative Medicineen_US
dc.subjectTem Microscopeen_US
dc.subjectRaten_US
dc.titleAn Examination of the Effects of Propolis and Quercetin in a Rat Model of Streptozotocin-Induced Diabetic Peripheral Neuropathyen_US
dc.typeArticleen_US

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