The Novel 5-Fluorouracil Loaded Ruthenium-based Nanocarriers Enhanced Anticancer and Apoptotic Efficiency while Reducing Multidrug Resistance in Colorectal Cancer Cells

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dc.authoridOzerkan, Dilsad/0000-0002-0556-3879
dc.authorwosidOzerkan, Dilsad/AAC-3485-2021
dc.contributor.authorDanisman-Kalindemirtas, Ferdane
dc.contributor.authorOzerkan, Dilsad
dc.contributor.authorKariper, Ishak Afsin
dc.contributor.authorBulut, Huri
dc.date.accessioned2024-05-19T14:46:34Z
dc.date.available2024-05-19T14:46:34Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractRecently, nanocarriers have been made to eliminate the disadvantages of chemotherapeutic agents by nanocarriers. Nanocarriers show their efficacy through their targeted and controlled release. In this study, 5-fluorouracil (5FU) was loaded into ruthenium (Ru)-based nanocarrier (5FU-RuNPs) for the first time to eliminate the disadvantages of 5FU, and its cytotoxic and apoptotic effects on HCT116 colorectal cancer cells were compared with free 5FU. 5FU-RuNPs with a size of approximately 100 nm showed a 2.61-fold higher cytotoxic effect compared to free 5FU. Apoptotic cells were detected by Hoechst/propidium iodide double staining, and the expression levels of BAX/Bcl-2 and p53 proteins, in which apoptosis occurred intrinsically, were revealed. In addition, 5FU-RuNPs was also found to reduce multidrug resistance (MDR) according to BCRP/ABCG2 gene expression levels. When all the results were evaluated, the fact that Ru-based nanocarriers alone did not cause cytotoxicity proved that they were ideal nanocarriers. Moreover, 5FU-RuNPs did not show any significant effect on the cell viability of normal human epithelial cell lines BEAS-2B. Consequently, the 5FU-RuNPs synthesized for the first time may be ideal candidates for cancer treatment because they can minimize the potential drawbacks of free 5FU.en_US
dc.identifier.doi10.1007/s10895-023-03180-9
dc.identifier.endpage1236en_US
dc.identifier.issn1053-0509
dc.identifier.issn1573-4994
dc.identifier.issue3en_US
dc.identifier.pmid36811696en_US
dc.identifier.scopus2-s2.0-85148522595en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1227en_US
dc.identifier.urihttps://doi.org10.1007/s10895-023-03180-9
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5549
dc.identifier.volume33en_US
dc.identifier.wosWOS:000936252100002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofJournal of Fluorescenceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectRuthenium-Based Nanoparticlesen_US
dc.subject5fuen_US
dc.subjectColorectal Canceren_US
dc.subjectApoptosisen_US
dc.subjectCytotoxicityen_US
dc.titleThe Novel 5-Fluorouracil Loaded Ruthenium-based Nanocarriers Enhanced Anticancer and Apoptotic Efficiency while Reducing Multidrug Resistance in Colorectal Cancer Cellsen_US
dc.typeArticleen_US

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