Targeted regulation of autophagy using nanoparticles: New insight into cancer therapy

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dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100
dc.authorwosidAli Zarrabi / U-2602-2019
dc.contributor.authorPaskeh, Mahshid Deldar Abad
dc.contributor.authorEntezari, Maliheh
dc.contributor.authorClark, Courtney
dc.contributor.authorZabolian, Amirhossein
dc.contributor.authorRanjbar, Ehsan
dc.contributor.authorZarrabi, Ali
dc.date.accessioned2022-01-14T08:49:03Z
dc.date.available2022-01-14T08:49:03Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractNormal cells depend on autophagy to maintain cellular homeostasis by recycling damaged organelles and misfolded proteins and degrading toxic agents. Similar to apoptosis, targeting autophagy has been under attention in cancer therapy. However, autophagy has both pro-survival and pro-death functions in tumors, and its targeting requires further elucidation. The current review focuses on using nanoparticles for targeting autophagy in cancer treatment. Nanocarriers can deliver autophagy regulators along with chemotherapeutic agents leading to intracellular accumulation in cancer cells and synergistic cancer therapy. Furthermore, genetic tools such as siRNA and shRNA can be used for targeting molecular components that regulate autophagy, such as the ATG12-ATG5-ATG16L1 complex. A number of nanostructures, such as gold and zinc oxide nanoparticles, can be used to enhance oxidative stress-mediated apoptosis and autophagy, reducing cancer progression. Further, using nanoparticles to modulate autophagy potentiates the anti-tumor effects of cisplatin and gefitinib during chemotherapy. Polymeric nanoparticles, lipid-based nanostructures and carbon-based nanomaterials are among other nanoparticles capable of regulating autophagy in cancer cells. Of note, various regulatory components of autophagy such as ATGs, Beclin-1 and LC3-II can be affected by nanomaterials. Based on the role of nanomaterial-induced autophagy as pro-survival or pro-death, further targeting can potentiate the fight against cancer cells. © 2021 Elsevier B.V.en_US
dc.identifier.citationPaskeh, M. D. A., Entezari, M., Clark, C., Zabolian, A., Ranjbar, E., Farahani, M. V., ... & Łos, M. J. (2022). Targeted regulation of autophagy using nanoparticles: New insight into cancer therapy. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 166326.en_US
dc.identifier.doi10.1016/j.bbadis.2021.166326en_US
dc.identifier.issn0925-4439en_US
dc.identifier.issue3en_US
dc.identifier.pmid34942307en_US
dc.identifier.scopus2-s2.0-85122089646en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.bbadis.2021.166326
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2386
dc.identifier.volume1868en_US
dc.identifier.wosWOS:000794036200006en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofBBA - Molecular Basis of Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutophagyen_US
dc.subjectCell Deathen_US
dc.subjectChemotherapyen_US
dc.subjectDrug Deliveryen_US
dc.subjectGene Therapyen_US
dc.subjectNanoparticlesen_US
dc.titleTargeted regulation of autophagy using nanoparticles: New insight into cancer therapyen_US
dc.typeArticleen_US

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