CD123 immunoexpression in cutaneous lupus erythematosus, polymorphous light eruption, pityriasis rosea, and mycosis fungoides

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dc.authoridEbru Karagün / 0000-0002-5032-7429
dc.authorscopusidEbru Karagün / 55587304900
dc.authorwosidEbru Karagün / ABB-7919-2020
dc.contributor.authorKaragün, Ebru
dc.contributor.authorGamsızkan, Mehmet
dc.contributor.authorBüyücek, Şeyma
dc.contributor.authorCoşkun, Sinem
dc.date.accessioned2022-02-01T05:50:18Z
dc.date.available2022-02-01T05:50:18Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroduction: CD123-positive plasmacytoid dendrocytes are prominent in the infiltrate of cutaneous lupus erythematous. Aim: To determine the significance of the CD123 immunostain, which labels plasmacytoid dendritic cells (PDC), in cutaneous lupus erythematous (CLE), polymorphous light eruption (PLE), pityriasis rosea (PR) and mycosis fungoides Material and methods: A total of 76 cases, including MF (n = 27), CLE (n = 19), PR (n = 19), and PLE (n = 11), were included in the study after reviewing their diagnostic clinical features and pathologic findings. The primary antibody against CD123 was performed in all cases. Results: CD123+ immunostaining in PDCs was positive in all cases. The highest mean percentage was noted in CLE (15.2%), followed by PLE (15%), PR (8.8%), and MF (2%). Besides, the clustering of CD123-positive cells was significant in CLE and PLE compared to MF and PR. Conclusions: PDC may have an important role in the aetiology of PLE and CLE cases. CD123 is a useful marker for differentiating CLE and PLE from MF and PR.en_US
dc.identifier.citationKaragun, E., Gamsizkan, M., Buyucek, S., & Coskun, S. (2021). CD123 immunoexpression in cutaneous lupus erythematosus, polymorphous light eruption, pityriasis rosea, and mycosis fungoides. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 38(6), 994-1000.en_US
dc.identifier.doi10.5114/ada.2020.100336en_US
dc.identifier.endpage1000en_US
dc.identifier.issn1642-395Xen_US
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85123727249en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage994en_US
dc.identifier.urihttps://doi.org/10.5114/ada.2020.100336
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2448
dc.identifier.volume38en_US
dc.identifier.wosWOS:000744086600002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKaragün, Ebru
dc.language.isoenen_US
dc.publisherTERMEDIA PUBLISHING HOUSE LTDen_US
dc.relation.ispartofPOSTEPY DERMATOLOGII I ALERGOLOGIIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCD123en_US
dc.subjectCutaneous Lupus Erythematousen_US
dc.subjectLight Eruptionen_US
dc.subjectMycosis Fungoidesen_US
dc.subjectPityriasis Roseaen_US
dc.titleCD123 immunoexpression in cutaneous lupus erythematosus, polymorphous light eruption, pityriasis rosea, and mycosis fungoidesen_US
dc.typeArticleen_US

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