Adverse events in children and adolescents undergoing allergen immunotherapy for respiratory allergies-Report from the Allergen Immunotherapy Adverse Events Registry (ADER), a European Academy of Allergy and Clinical Immunology taskforce

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dc.authoridChristoff, George/0000-0003-4549-7711
dc.authoridPapadopoulos, Nikolaos G./0000-0002-4448-3468
dc.authoridPapadopoulos, Nikolaos/0000-0002-4448-3468
dc.authoridAsllani, Julijana/0009-0003-1493-7101
dc.authoridKonstantinou, George/0000-0003-1371-6764
dc.authoridShehu, Esmeralda/0009-0004-7204-1976
dc.authoridAGGELIDIS, XENOFON/0000-0003-1715-3022
dc.authorwosidChristoff, George/ABF-9789-2021
dc.authorwosidPapadopoulos, Nikolaos G./L-8670-2013
dc.authorwosidPapadopoulos, Nikolaos/ABE-1774-2021
dc.contributor.authorAsllani, Julijana
dc.contributor.authorMitsias, Dimitrios
dc.contributor.authorKonstantinou, George
dc.contributor.authorMesonjesi, Eris
dc.contributor.authorXhixha, Fatmira
dc.contributor.authorShehu, Esmeralda
dc.contributor.authorChristoff, George
dc.date.accessioned2024-05-19T14:38:54Z
dc.date.available2024-05-19T14:38:54Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBackgroundAlthough it has been shown that allergen immunotherapy (AIT) is well-tolerated in children, systematic and prospective surveillance of AIT safety in real life settings is needed. MethodsThe multinational Allergen Immunotherapy Adverse Events Registry (ADER) was designed to address AIT safety in real life clinical practice. Data on children <= 18 years old with respiratory allergies undergoing AIT were retrieved. Patient- and AIT-related features were collected and analyzed. The characteristics of adverse events (AE) and risk factors were evaluated. ResultsA total of 851 patients, 11.3 +/- 3.4 years old, with rhinitis only (47.6%); asthma and rhinitis (44.5%); asthma (7.9%), receiving 998 AIT courses were analyzed. Sublingual immunotherapy (SLIT) accounted for 51% of the courses. In 84.5% of patients only one AIT treatment was prescribed. Pollen was the most frequent sensitizer (57.1%), followed by mites (53.4%), molds (18.2%) and epithelia (16.7%). Local and systemic AEs were reported in 85 patients (9.9%). Most AEs (83.1%) were mild and occurred in <30 min (87%). Respiratory and cutaneous symptoms were more frequent. Only 4 patients (0.47%) had severe AE (none after 6 weeks of maintenance). The risk of AE was higher in patients undergoing SCIT. ConclusionsAIT is safe and well tolerated in children and adolescents with respiratory allergies in real-life clinical practice. Though SCIT is more prone to AE compared to SLIT, overall severe reactions are rare and occur during build-up and early maintenance.en_US
dc.description.sponsorshipStallergenes; European Academy of Allergy and Clinical Immunologyen_US
dc.description.sponsorshipStallergenes; European Academy of Allergy and Clinical Immunologyen_US
dc.identifier.doi10.1002/clt2.12250
dc.identifier.issn2045-7022
dc.identifier.issue6en_US
dc.identifier.pmid37357552en_US
dc.identifier.urihttps://doi.org10.1002/clt2.12250
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4644
dc.identifier.volume13en_US
dc.identifier.wosWOS:000999611000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofClinical and Translational Allergyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectAdverse Eventsen_US
dc.subjectAllergen Immunotherapyen_US
dc.subjectReal-Life Settingsen_US
dc.subjectRisk Factorsen_US
dc.titleAdverse events in children and adolescents undergoing allergen immunotherapy for respiratory allergies-Report from the Allergen Immunotherapy Adverse Events Registry (ADER), a European Academy of Allergy and Clinical Immunology taskforceen_US
dc.typeArticleen_US

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