Role of caspase-9 gene Ex5+32 G > A (rs1052576) variant in susceptibility to primary brain tumors

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dc.authoridUzay Görmüş / 0000-0002-3124-0184
dc.authorscopusidUzay Görmüş / 16230182400
dc.authorwosidUzay Görmüş / JKU-7676-2023
dc.contributor.authorÖzdoğan, Selçuk
dc.contributor.authorKafadar, Ali
dc.contributor.authorYılmaz, Seda Güleç
dc.contributor.authorTimirci-Kahraman, Özlem
dc.contributor.authorGörmüş, Uzay
dc.contributor.authorİşbir, Turgay
dc.date.accessioned2020-08-30T20:08:04Z
dc.date.available2020-08-30T20:08:04Z
dc.date.issued2017
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground/Aim: This study is the first to evaluate the relationship of caspase-9 (CASP-9) gene polymorphism with the risk for primary brain tumor development. Materials and Methods: The study group included 43 glioma and 27 meningioma patients and 76 healthy individuals. CASP-9 gene Ex5+32 G>A (rs1052576) polymorphism was analyzed by real-time polymerase chain reaction (RT-PCR). Results: Individuals with the CASP-9 GG genotype had significantly decreased risk of developing a glioma brain tumor (p=0.024). Additionally, the GA genotype was significantly lower in patients with glioma than the control group (p=0.019). A significantly decreased risk of developing glioma was found in the A allele carrier group (p=0.024). However, there was no statistically significant relationship between CASP-9 polymorphism and brain meningioma (p=0.493). Conclusion: CASP-9 (rs1052576) mutant A allele seems to be a protective factor for glioma brain tumor. Future studies with a larger sample size will clarify the possible roles of CASP-9 gene in the etiology and progression of primary brain tumors.en_US
dc.identifier.citationOzdogan, S., Kafadar, A., Yilmaz, S. G., Timirci-Kahraman, O., Gormus, U., & Isbir, T. (2017). Role of Caspase-9 Gene Ex5+ 32 G> A (rs1052576) Variant in Susceptibility to Primary Brain Tumors. Anticancer Research, 37(9), 4997-5000.en_US
dc.identifier.doi10.21873/anticanres.11912en_US
dc.identifier.endpage5000en_US
dc.identifier.issn0250-7005en_US
dc.identifier.issn1791-7530en_US
dc.identifier.issue9en_US
dc.identifier.pmid28870924en_US
dc.identifier.scopus2-s2.0-85029433299en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage4997en_US
dc.identifier.urihttps://doi.org/10.21873/anticanres.11912
dc.identifier.urihttps://hdl.handle.net/20.500.12713/879
dc.identifier.volume37en_US
dc.identifier.wosWOS:000412578200035en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGörmüş, Uzayen_US
dc.language.isoenen_US
dc.publisherInt Inst Anticancer Researchen_US
dc.relation.ispartofAnticancer Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCaspase-9en_US
dc.subjectGliomaen_US
dc.subjectMeningiomaen_US
dc.subjectPolymorphismen_US
dc.titleRole of caspase-9 gene Ex5+32 G > A (rs1052576) variant in susceptibility to primary brain tumorsen_US
dc.typeArticleen_US

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