Blood based biomarkers as predictive factors for hyperprogressive disease

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dc.authoridSaadettin Kılıçkap / 0000-0003-1637-7390
dc.authorscopusidSaadettin Kılıçkap / 8665552100
dc.authorwosidSaadettin Kılıçkap / DXP-4273-2022en_US
dc.contributor.authorYıldırım, Hasan Çağrı
dc.contributor.authorGüven, Deniz Can
dc.contributor.authorAktepe, Oktay Halit
dc.contributor.authorTaban, Hakan
dc.contributor.authorYılmaz, Feride
dc.contributor.authorYasar, Serkan
dc.contributor.authorAksoy, Sercan
dc.contributor.authorErman, Mustafa
dc.contributor.authorKılıçkap, Saadettin
dc.contributor.authorYalçın, Suayib
dc.date.accessioned2022-09-19T14:10:52Z
dc.date.available2022-09-19T14:10:52Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: With the widespread use of immunotherapy agents, we encounter treatment responses such as hyperprogression disease (HPD) that we have not seen with previous standard chemotherapy and targeted therapies. It is known that survival in patients with HPD is shorter than in patients without HPD. Therefore, it is important to know the factors that will predict HPD. We aimed to identify HPD-related factors in patients treated with immunotherapy. Methods: A total of 121 adult metastatic cancer patients treated with immunotherapy for any cancer were included. Baseline demographics, the ECOG performance status, type of tumors and baseline blood count parameters were recorded. Possible predisposing factors were evaluated with univariate and multivariate analyses. Results: The median age was 62.28 (interquartile range (IQR) 54.02-67.63) years, and the median follow-up was 12.26 (IQR 5.6-24.36) months. Renal cell carcinoma (33%) and melanoma (33.8%) were the most common diagnoses. Twenty patients (16.5%) had HPD. A high LDH level (p: 0.001), hypoalbuminemia (p: 0.016) and an NLR > 5 (p: 0.007) were found to be associated with hyperprogression. Sex (female vs. male, p: 0.114), age (>65 vs. <65, p: 0.772), ECOG (0 vs. 1-4, p: 0.480) and the line of treatment (1-5, p: 0.112) were not found to be associated with hyperprogression. Conclusions: In this study, we observed HPD in 16.5% of immunotherapy-treated patients and increased HPD risk in patients with a high LDH level (p: 0.001), hypoalbuminemia (p: 0.016) and an NLR > 5 (p: 0.007).en_US
dc.identifier.citationYildirim, H. C., Guven, D. C., Aktepe, O. H., Taban, H., Yilmaz, F., Yasar, S., Aksoy, S., Erman, M., Kilickap, S., Yalcin, S. (2022). Blood based biomarkers as predictive factors for hyperprogressive disease. Journal of Clinical Medicine, 11(17).en_US
dc.identifier.doi10.3390/jcm11175171en_US
dc.identifier.issn2077-0383en_US
dc.identifier.issue17en_US
dc.identifier.scopus2-s2.0-85137831621en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/jcm11175171
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3163
dc.identifier.volume11en_US
dc.identifier.wosWOS:000851123400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKılıçkap, Saadettin
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofJOURNAL OF CLINICAL MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectImmunotherapyen_US
dc.subjectHyperprogressionen_US
dc.subjectHPDen_US
dc.subjectNLRen_US
dc.subjectHypoalbuminemiaen_US
dc.titleBlood based biomarkers as predictive factors for hyperprogressive diseaseen_US
dc.typeArticleen_US

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