It is time to revitalize the Antibiotic Pipeline: Systems ecology can help

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dc.authoridSemra Şardaş / 0000-0001-5456-8636en_US
dc.authoridAyşe Şeyma Büyük / 0000-0001-8934-0359en_US
dc.authorscopusidSemra Şardaş / 7003286974
dc.authorscopusidAyşe Şeyma Büyük / 57215857903
dc.authorwosidSemra Şardaş / J-2175-2018
dc.authorwosidAyşe Şeyma Büyük / AAM-1484-2020
dc.contributor.authorŞardaş, Semra
dc.contributor.authorBüyük, Ayşe Şeyma
dc.contributor.authorBeceren, Ayfer
dc.date.accessioned2020-08-30T20:06:15Z
dc.date.available2020-08-30T20:06:15Z
dc.date.issued2020
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümüen_US
dc.descriptionSardas, Semra/0000-0001-5456-8636; Buyuk, Ayse Seyma/0000-0001-8934-0359en_US
dc.description.abstractAntimicrobials have been known for millennia, but innovative antibiotics are currently in short supply. New antimicrobial discoveries are being threatened by planetary scale loss of biodiversity that has important impacts on species and ecosystems. This expert review underscores that microorganisms in nature and their diversity are essential cornerstones to revitalize the antibiotic innovation and discovery pipeline. The recent rise of systems ecology and planetary health offers new and actionable potentials in this regard. Without a systems scale focus and appreciation of systems ecology, the global threats to human and planetary health from inappropriate use of antibiotics and antimicrobial resistance will continue to escalate with serious consequences to all life on the planet. With acutely pressing research and development needs to revitalize antibiotic treatment and novel diagnostic tools for personalized medicine, national health systems ought to work across knowledge silos not only within but also across the ministries, for example, health, agriculture, environment, economy, trade, and social services ministries that collectively impact on systems ecology and by extension on health innovations including the antibiotic discovery pipeline. Such systems vision can also help to revitalize antibiotic discovery pipeline as most antibiotics have natural origins or have designs inspired or based on molecules in the environment and microorganisms that produce antibiotics. Above all, our audience and responsibility include every person who has an interest in his or her own health, in the health of his or her fellow human beings and all life on the planet, and in the health of future generations.en_US
dc.identifier.citationSardas, S., Buyuk, A. S., & Beceren, A. (2020). It Is Time to Revitalize the Antibiotic Pipeline: Systems Ecology Can Help. OMICS: A Journal of Integrative Biology, 24(3), 124-128.en_US
dc.identifier.doi10.1089/omi.2020.0008en_US
dc.identifier.endpage128en_US
dc.identifier.issn1536-2310en_US
dc.identifier.issn1557-8100en_US
dc.identifier.issue3en_US
dc.identifier.pmid32073984en_US
dc.identifier.scopus2-s2.0-85082108976en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage124en_US
dc.identifier.urihttps://doi.org/10.1089/omi.2020.0008
dc.identifier.urihttps://hdl.handle.net/20.500.12713/446
dc.identifier.volume24en_US
dc.identifier.wosWOS:000515387600001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorŞardaş, Semraen_US
dc.institutionauthorBüyük, Ayşe Şeymaen_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofOmics-A Journal of Integrative Biologyen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibioticsen_US
dc.subjectSystems Ecologyen_US
dc.subjectNational Innovation Systemsen_US
dc.subjectSystems Pharmacyen_US
dc.subjectDrug Discoveryen_US
dc.subjectPlanetary Healthen_US
dc.titleIt is time to revitalize the Antibiotic Pipeline: Systems ecology can helpen_US
dc.typeReview Articleen_US

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