Treat to target and tight control: Could be a new approach in the treatment of sarcoidosis?
Küçük Resim Yok
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Int Research & Cooperation Assoc Bio & Socio-Sciences Advancement
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Sarcoidosis is a chronic granulomatous disease with multisystemic involvement. Although it is accepted as a benign disease, it can sometimes cause life-threatening organ (heart, brain) involvement that determines the prognosis of the disease. There are conflicting opinions about the treatment of the disease. In the generally accepted treatment approach the step-by-step model has gained weight. According to this approach, corticosteroids (CS) drugs alone are preferred in the first step in patients who require treatment. In the second step, immunosuppressive drugs (IS) are used in patients who do not respond to CS and/or have contraindications to CS use, and biologics (TNF-alpha inhibitors) are used in the third step. This treatment approach may be valid in cases with mild sarcoidosis. However, although sarcoidosis is considered a benign and self-limiting disease in some major organ involvement, the step-by-step approach may be a treatment option that puts the patient's life in danger. In such selected patients, much more rigorous, early and combined treatment approaches that definitely include CS, IS or biologic drugs may be required. In selected sarcoidosis patients with high risk, early diagnosis, treat-to-target (T2T) and tight control follow-up of patients seems to be a rational approach. This article reviews the step-down treatment regimens in light of recent literature data and hypothesizes that the T2T model may be a probable new treatment approach in patients with sarcoidosis.
Açıklama
Anahtar Kelimeler
Sarcoidosis, Treat -To -Target, Tight Control, Remission, New Approach
Kaynak
Intractable & Rare Diseases Research
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
12
Sayı
1
