Water-soluble copper(II) 5-fluorouracil complexes bearing polypyridyl co-ligands: synthesis, structures and anticancer activity

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dc.authoridAygün, Muhittin/0000-0001-9670-9062
dc.authoridYilmaz, Veysel Turan/0000-0002-2849-3332
dc.authoridIcsel, Ceyda/0000-0002-2717-2430
dc.authorwosidAygün, Muhittin/E-9590-2011
dc.authorwosidYilmaz, Veysel Turan/L-7238-2018
dc.contributor.authorIcsel, Ceyda
dc.contributor.authorYilmaz, Veysel T.
dc.contributor.authorAygun, Muhittin
dc.contributor.authorErkisa, Merve
dc.contributor.authorUlukaya, Engin
dc.date.accessioned2024-05-19T14:50:37Z
dc.date.available2024-05-19T14:50:37Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractFive newly synthesized copper(II) 5-fluorouracil (5-FU) complexes of polypyridyl co-ligands with good solubility in water, namely [CuCl(5-FU)(bpy)(DMSO)] (1), [Cu(5-FU)(phen)(2)](5-FU)center dot 4H(2)O (2), [Cu(5-FU)(dpya)(2)](NO3)center dot 2.5H(2)O (3), [Cu(5-FU)(NO3)(bpyma)]center dot H2O (4) and [CuCl(5-FU)(terpy)] (5) (bpy = 2,2 '-bipyridine, phen = 1,10-phenanthroline, dpya = 2,2 '-dipyridylamine, bpyma = bis(2-pyridylmethyl)amine and terpy = 2,2 ';6 ',2 ''-terpyridine), were characterized by elemental analysis and a number of spectrometric methods. The structures of complexes 1-5 were determined by X-ray crystallography and the copper(II) ions were five coordinate. Cytotoxic activity of the complexes in four human cancer cell lines, A549 (lung carcinoma), MDA-MB-231 (breast carcinoma), HCT116 (colon carcinoma) and DU145 (prostate carcinoma), and a normal cell line, BEAS-2B (human lung epithelial), was determined by SRB assay and compared with that of 5-FU and cisplatin. The complexation of 5-FU together with polypyridyl ligands resulted in a significant increase in the cytotoxicity of the complexes, with complex 2 exhibiting the highest anticancer potency against all the cell lines, with HCT116 being the most sensitive. The mode of action of cell death for 2 was investigated using morphological imaging and cytometric analyses, including the capacity for induction of apoptosis, generation of reactive oxygen species, mitochondrial dysfunction and DNA damage.en_US
dc.description.sponsorshipBursa Uludag University [OUAP(F) 2020/10]; Karadeniz Technical Universityen_US
dc.description.sponsorshipThis work was supported by Bursa Uludag University (project no.: OUAP(F) 2020/10). We also thank Karadeniz Technical University for additional financial support.en_US
dc.identifier.doi10.1039/d3dt00363a
dc.identifier.endpage7058en_US
dc.identifier.issn1477-9226
dc.identifier.issn1477-9234
dc.identifier.issue21en_US
dc.identifier.pmid36939483en_US
dc.identifier.scopus2-s2.0-85160869888en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage7048en_US
dc.identifier.urihttps://doi.org10.1039/d3dt00363a
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5761
dc.identifier.volume52en_US
dc.identifier.wosWOS:000996351200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofDalton Transactionsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subject[No Keywords]en_US
dc.titleWater-soluble copper(II) 5-fluorouracil complexes bearing polypyridyl co-ligands: synthesis, structures and anticancer activityen_US
dc.typeArticleen_US

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