Impact of postnatal nutrition on neurodevelopmental outcome in rat model of intrauterine growth restriction

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dc.authoridBora Baysal / 0000-0002-2156-0758en_US
dc.authorscopusidBora Baysal / 57194685508en_US
dc.authorwosidBora Baysal / AFR-7500-2022
dc.contributor.authorBaysal, Bora
dc.contributor.authorCilaker Mıçılı, Serap
dc.contributor.authorEngür, Defne
dc.contributor.authorAkokay, Pınar
dc.contributor.authorKarabulut, A.R.
dc.contributor.authorKeskinoğlu, Pembe
dc.contributor.authorYılmaz, Osman
dc.contributor.authorKumral, Abdullah
dc.date.accessioned2022-11-14T11:29:19Z
dc.date.available2022-11-14T11:29:19Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractOBJECTIVE: There are limited data on nutritional management of infants with intrauterine growth restriction (IUGR). Postnatal protein supplementation for promoting growth is a common clinical practice in neonatology. The present study aims to investigate the consequences of protein supplementation on long-term growth, brain and body weight, brain histology and behavioral outcome in a rat model of IUGR. MATERIALS AND METHODS: Twenty-four IUGR-formed rat puppies and 12 healthy puppies were included in the study. IUGR model was established by low (10%) protein diet throughout pregnancy together with intraperitoneal injection of lipopolysaccharide (LPS). Pups were started to be fed with either standard protein (SP), or high protein (HP) diet until postnatal day (PN) 35. Puppies in the control group were given SP diet for 35 days. Six pups from each group were sacrificed at PN7, remaining six were evaluated by Morris water maze test between PN 30 to 35 days and then sacrificed at PN35. Histologic evaluation of brain tissue was performed at PN7 and PN35. RESULTS: IUGR group displayed lower body and brain weights at PN7 when compared with control. At PN35, SP group achieved similar brain/body weight ratios with control, whereas HP group displayed lowest brain/body weight ratio. The number of TUNEL positive cells was significantly higher and myelin basic protein and oligodendrocyte marker O4 immunoreactivity were significantly lower in HP group when compared with SP at PN35. Neuronal density in prefrontal cortex and hippocampus at PN7 were similar among SP and HP groups, but significantly lower in HP group when compared with SP at PN35. SP group displayed better results in the Morris water maze test when compared with HP group. CONCLUSIONS: Although postnatal HP support is associated with increase in body weight at PN35, it did not result in better brain/body weight ratios in the rat model of IUGR. In IUGR rats, HP diet was associated with increased apoptosis in brain tissue with lower neuronal density and decreased myelination when compared to SP. Furthermore, better neurodevelopmental scores were achieved by SP diet rather than HP support in IUGR.en_US
dc.identifier.citationBaysal, B., Miçili, S., Engür, D., Akokay, P., Karabulut, A. R., Keskinoğlu, P., . . . Kumral, A. (2022). Impact of postnatal nutrition on neurodevelopmental outcome in rat model of intrauterine growth restriction. European Review for Medical and Pharmacological Sciences, 26(20), 7498-7505. doi:10.26355/eurrev_202210_30020en_US
dc.identifier.doi10.26355/eurrev_202210_30020en_US
dc.identifier.endpage7505en_US
dc.identifier.issue20en_US
dc.identifier.scopus2-s2.0-85141003873en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage7498en_US
dc.identifier.urihttps://doi.org/10.26355/eurrev_202210_30020
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3380
dc.identifier.volume26en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBaysal, Bora
dc.language.isoenen_US
dc.publisherNLM (Medline)en_US
dc.relation.ispartofEuropean review for medical and pharmacological sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleImpact of postnatal nutrition on neurodevelopmental outcome in rat model of intrauterine growth restrictionen_US
dc.typeArticleen_US

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