Prognostic significance of prolonged corrected QT interval in cerebral contusion

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dc.authoridBaskurt, Ozan/0000-0003-1021-6529
dc.authoridAvci, Idris/0000-0002-0378-9356
dc.authorwosidBaskurt, Ozan/AAH-3664-2020
dc.authorwosidAvci, Idris/KIJ-4343-2024
dc.contributor.authorYavuz, Ahmed Yasin
dc.contributor.authorBaskurt, Ozan
dc.contributor.authorKurtulus, Yunus
dc.contributor.authorAvci, Idris
dc.date.accessioned2024-05-19T14:39:50Z
dc.date.available2024-05-19T14:39:50Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBackground & objectives: Cerebral contusion (CC) results in a release of catecholamines, autonomic dysfunction and neural stimulation that can lead to a number of cardiac adverse events, so it is critical to determine these. So the objective of this study was to investigate the prognostic significance of electrocardiographic changes, particularly the effects of a prolonged corrected QT (QTc) interval in CC. Methods: In this retrospective cohort study, 110 patients with CC were evaluated. Age, sex, concomitant diseases, Glasgow Coma Scale on admission, radiological assessment of the contusion (location, size, course and presence of cerebral oedema), need for surgical intervention, length of hospital stay and the extended Glasgow Outcome Scale (GOS-E) were statistically analysed within the QTc interval by routine electrocardiography (ECG) on admission. Results: The prolonged QTc interval was found to be associated with a higher incidence of cerebral oedema and a significantly higher risk of needing surgery. Patients with a prolonged QTc interval had a significantly larger contusion volume, greater midline shift and longer hospital stay, so their GOS-E score was significantly lower. A prolonged QTc interval on admission resulted in a hospital stay of more than eight days (sensitivity: 0.97 and specificity: 0.86), a higher risk of midline shift of more than 0.45 cm (P=0.006, sensitivity: 0.80 and specificity: 0.99) and a GOS-E score of <7 (sensitivity: 0.97 and specificity: 0.85). Interpretation & conclusions: ECG changes on admission showing a prolonged QTc interval have prognostic significance in CC. This simple and easily applicable information should be taken into consideration at the time of clinical decision making which may prevent an adverse events survivor.en_US
dc.identifier.doi10.4103/ijmr.ijmr_3629_21
dc.identifier.endpage181en_US
dc.identifier.issn0971-5916
dc.identifier.issue2en_US
dc.identifier.pmid37706372en_US
dc.identifier.scopus2-s2.0-85173645228en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage175en_US
dc.identifier.urihttps://doi.org10.4103/ijmr.ijmr_3629_21
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4858
dc.identifier.volume158en_US
dc.identifier.wosWOS:001107147200010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofIndian Journal of Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectCardiac Side Effectsen_US
dc.subjectCerebral Contusionen_US
dc.subjectEcgen_US
dc.subjectPrognostic Significanceen_US
dc.subjectCorrected Qt Intervalen_US
dc.subjectTraumatic Brain Injuryen_US
dc.titlePrognostic significance of prolonged corrected QT interval in cerebral contusionen_US
dc.typeArticleen_US

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