Expression of survivin and its splice variants in pediatric acute lymphoblastic leukemia

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dc.authoridBaşak Adaklı Aksoy / 0000-0001-8338-2101
dc.authorscopusidBaşak Adaklı Aksoy / 8960776700
dc.authorwosidBaşak Adaklı Aksoy / AAK-3627-2021
dc.contributor.authorEren-Keleş, Efsun
dc.contributor.authorKarabulut, Halil Gürhan
dc.contributor.authorÇakmaklı, Hasan Fatih
dc.contributor.authorAdaklı Aksoy, Başak
dc.contributor.authorKöse, Serdar Kenan
dc.contributor.authorUğur-Dinçaslan, Handan
dc.contributor.authorYavuz, Gülsan
dc.contributor.authorErtem, Mehmet
dc.contributor.authorTükün, Ajlan
dc.date.accessioned2020-08-30T20:07:15Z
dc.date.available2020-08-30T20:07:15Z
dc.date.issued2018
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAims: Survivin is involved in the inhibition of apoptosis and the regulation of cell division. In addition to wild-type survivin (survivin-wt), at least four splice variants with differential functions (Delta Ex3 and 3B antiapoptotic, and 2 alpha and 2B proapoptotic) have been identified. Survivin is highly expressed in several cancers, including hematological malignancies. Although acute lymphoblastic leukemia (ALL) is the most frequent malignancy in children, studies that investigated survivin expression in ALL are limited, and there is no study on 3B and 2 alpha expression in ALL. Therefore the expression of survivin-wt and its splice variants was investigated in pediatric B-cell ALL patients. Materials and Methods: The expression of survivin-wt and its four splice variants was investigated by quantitative real-time polymerase chain reaction in archival RNA samples of 35 pediatric B-cell ALL patients. Patients were divided into high- and standard-risk groups according to age, white blood cell count, extramedullary involvement, and genetic risk factors; expression of survivin variants was compared between these two risk groups. Results: We found that the ratio of survivin-Delta Ex3/wild type (WT) expression was higher in the low-risk group than in the high-risk group. Conclusion: Comparative analysis between the high- and low-risk B-cell ALL groups indicated that survivin-Delta Ex3/WT expression ratio could potentially be used in risk classification for pediatric B-cell ALL.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [114S535]en_US
dc.description.sponsorshipThis project was supported by the Scientific and Technological Research Council of Turkey (TUBITAK, Project No. 114S535).en_US
dc.identifier.citationEren-Keles, E., Karabulut, H. G., Cakmakli, H. F., Adakli, B., Kose, S. K., Ugur-Dincaslan, H., … Tukun, A. (2018). Expression of Survivin and Its Splice Variants in Pediatric Acute Lymphoblastic Leukemia. GENETIC TESTING AND MOLECULAR BIOMARKERS, 22(12), 680–685. https://doi.org/10.1089/gtmb.2018.0152en_US
dc.identifier.doi10.1089/gtmb.2018.0152en_US
dc.identifier.endpage685en_US
dc.identifier.issn1945-0265en_US
dc.identifier.issn1945-0257en_US
dc.identifier.issue12en_US
dc.identifier.pmid30489176en_US
dc.identifier.scopus2-s2.0-85058505153en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage680en_US
dc.identifier.urihttps://doi.org/10.1089/gtmb.2018.0152
dc.identifier.urihttps://hdl.handle.net/20.500.12713/727
dc.identifier.volume22en_US
dc.identifier.wosWOS:000451529500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAdaklı Aksoy, Başaken_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofGenetic Testing and Molecular Biomarkersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPediatricsen_US
dc.subjectAcute Lymphoblastic Leukemiaen_US
dc.subjectPrecursor B-Cell Allen_US
dc.subjectSurvivinen_US
dc.subjectQuantitative Real-Time Pcren_US
dc.titleExpression of survivin and its splice variants in pediatric acute lymphoblastic leukemiaen_US
dc.typeArticleen_US

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