Developing multifunctional pectin-based hydrogel for wound dressing: In silico, in vitro and in vivo evaluation

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dc.authorscopusidAyça Bal Öztürk / 57062000100
dc.authorwosidAyça Bal Öztürk / KRG-6786-2024
dc.contributor.authorKocaağa, Banu
dc.contributor.authorÖztürk, Yetkin
dc.contributor.authorKurçin, H. Ceren
dc.contributor.authorGüner-Yılmaz, Ö. Zeynep
dc.contributor.authorKürkcüoğlu, Özge
dc.contributor.authorTatlıer, Melkon
dc.contributor.authorÖzdemir, İlkay
dc.contributor.authorDemirci, Elif Kervancıoğlu
dc.contributor.authorKotil, Tuğba
dc.contributor.authorSolakoğlu, Seyhun
dc.contributor.authorAksu, Burak
dc.contributor.authorBatirel, Saime
dc.contributor.authorBal-Öztürk, Ayça
dc.contributor.authorGüner, F. Seniha
dc.date.accessioned2025-04-18T09:22:57Z
dc.date.available2025-04-18T09:22:57Z
dc.date.issued2024
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Temel Bilimleri Bölümü
dc.description.abstractMultifunctional hydrogel wound dressing with high hemostatic, antioxidant, and self-healing activity is desirable in clinical applications. In this contribution, we developed two distinct hydrogel formulations, namely PZ and PTBA, by employing low methoxyl pectin (P), zeolite, or 2-thiobarbituric acid (TBA) for sustained release of procaine (PC) in a controlled manner up to 40 h. These hydrogel systems (PZ and PTBA) utilize dynamic reversible hydrogen bonds between the components and a metal coordination bond between carboxyl acid groups of pectin chains and Ca2+ to confer self-healing properties, as demonstrated by molecular dynamics (MD) and rheological analyses. Moreover, PZ and PTBA hydrogels possess superior antioxidant, hemostasis, biocompatibility, and antibacterial activities. The data from the mouse skin incision model and infected full-thickness skin wound model demonstrated the highest wound closure rate (wound closure area per day) was achieved by the PZ (4.72) and PTBA (4.62) groups on day 21, which was better than the control (4.2) and Kaltostat groups (4.05) (p < 0.05). PZ and PTBA's effectiveness in wound closure and acceleration of the wound healing process, highlighting its significant potential in wound management.
dc.identifier.citationKocaağa, B., Öztürk, Y., Kurçin, H. C., Güner-Yılmaz, Ö. Z., Kurkcuoglu, O., Tatlier, M., ... & Güner, F. S. (2024). Developing multifunctional pectin-based hydrogel for wound dressing: In silico, in vitro and in vivo evaluation. European Polymer Journal, 216, 113280.
dc.identifier.doi10.1016/j.eurpolymj.2024.113280
dc.identifier.endpage22
dc.identifier.issn0014-3057
dc.identifier.issn1873-1945
dc.identifier.scopus2-s2.0-85197524120
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttp://dx.doi.org/10.1016/j.eurpolymj.2024.113280
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6771
dc.identifier.volume216
dc.identifier.wosWOS:001266920400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorBal-Öztürk, Ayça
dc.institutionauthoridAyça Bal Öztürk / 0000-0002-6502-528X
dc.language.isoen
dc.publisherPergamon-elsevier science
dc.relation.ispartofEuropean polymer journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.relation.tubitakARDEB 1002
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPectin
dc.subjectWound Healing
dc.subjectZeolite
dc.subjectMolecular Dynamics
dc.titleDeveloping multifunctional pectin-based hydrogel for wound dressing: In silico, in vitro and in vivo evaluation
dc.typeArticle

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