Synthesis, Characterization and Apoptosis Capabilities of a Novel Naphthoquinone-Derived Compound in Triple-Negative Breast Cancer

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dc.authoridGOKMEN, Zeliha/0000-0002-6848-1547
dc.authoridAKAR, Okan/0000-0001-8687-2034
dc.authorwosidGOKMEN, Zeliha/C-7274-2019
dc.contributor.authorAdacan, Kaan
dc.contributor.authorGokmen, Zeliha
dc.contributor.authorOkan Akar, Remzi
dc.contributor.authorOzyildiz, Zeynep
dc.contributor.authorDincer, Hatice
dc.contributor.authorKarakas, Didem
dc.contributor.authorUlukaya, Engin
dc.date.accessioned2024-05-19T14:45:58Z
dc.date.available2024-05-19T14:45:58Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBreast cancer is the most frequently diagnosed cancer in women and the second leading cause of cancer-related deaths. Because triple-negative breast cancer (TNBC) is highly resistant to clinically employed drugs, developing new drugs and treatment approaches is imperative. Naphthoquinone compounds potentially induce cancer cell death, and their clinical derivatives have been widely used as medicines. This study presents the synthesis and structure of a newly substituted naphthoquinone compound, as determined by spectroscopic techniques, then assesses the compound's ability to induce cell death on the MDA-MB-231 cell line using SRB viability testing, flow cytometry, and Western Blotting. The study also examines the compound's inhibition of cell migration through a scratch assay. The study discovered that the compound demonstrated an antigrowth/cytotoxic impact at concentrations of 3.12 mu M and beyond. The cytotoxicity may have been caused by elevated reactive oxygen species, which resulted in DNA damage. The mode of cell death was apoptotic, confirmed by the translocation of phosphatidylserine, the activation of caspases, and the disruption of the mitochondrial membrane potential. The compound seems promising as a new anti-malignant agent to be used for the treatment of breast cancer and deserves further attention for proof-of-concept in animal studies. Breast cancer, the most prevalent female cancer and second-leading cancer cause of death, includes the aggressive TNBC variant. Naphthoquinone compounds show promise in TNBC treatment. Recent research reveals a novel naphthoquinone's potential in inducing apoptosis at concentrations >= 3.12 mu M, possibly via ROS elevation, DNA damage, and apoptotic cell death. Its ability to hinder cell migration suggests anti-metastatic properties. Yet, thorough research, including animal model validation and human safety and efficacy assessments, is crucial before deeming it a viable TNBC treatment.imageen_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Istanbul University-Cerrahpasa [FYL-2019-33459]; Scientific Research Projects Coordination Unit of Istinye University [2020/B3]en_US
dc.description.sponsorshipThis study was funded by the Scientific Research Projects Coordination Unit of Istanbul University-Cerrahpasa, project number: FYL-2019-33459, and Scientific Research Projects Coordination Unit of Istinye University, project number 2020/B3.en_US
dc.identifier.doi10.1002/slct.202301955
dc.identifier.issn2365-6549
dc.identifier.issue43en_US
dc.identifier.scopus2-s2.0-85177189772en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org10.1002/slct.202301955
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5404
dc.identifier.volume8en_US
dc.identifier.wosWOS:001107710600030en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemistryselecten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectNaphthoquinoneen_US
dc.subjectCytotoxicityen_US
dc.subjectGenotoxicityen_US
dc.subjectAnti-Cancer Drugen_US
dc.subjectChemotherapyen_US
dc.subjectMammary Tumoren_US
dc.titleSynthesis, Characterization and Apoptosis Capabilities of a Novel Naphthoquinone-Derived Compound in Triple-Negative Breast Canceren_US
dc.typeArticleen_US

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