Is adrenomedullin upregulation due to apical periodontitis independent of periodontal disease?

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dc.authoridİlbey Kayra Özçelik / 0000-0002-1774-9689en_US
dc.authorwosidİlbey Kayra Özçelik / HGY-8662-2022
dc.contributor.authorErsahan, Şeyda
dc.contributor.authorÖzçelik, Fatih
dc.contributor.authorŞirin, Dursun Ali
dc.contributor.authorHepsenoğlu, Yelda Erdem
dc.contributor.authorÖzçelik, İlbey Kayra
dc.contributor.authorTopbaş, Celalettin
dc.date.accessioned2022-12-08T08:12:44Z
dc.date.available2022-12-08T08:12:44Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractTo investigate the relationship between apical periodontitis [AP] severity and inflammatory markers [interleukin (IL)-12, tumor necrosis factor-alpha (TNF-alpha), and Mid-Regional Pro Adrenomedullin (MR-proADM)] in patients with AP. A total of 162 subjects were divided into three categories: AP group (n=80), periodontitis (P) group (n= 42), healthy control group (n = 40). The scoring of disease severity in 80 AP patients without any periodontal disease, using dental radiographs, was based on The Abscess Score (AS), as those having at least 1 tooth with AP and severity of PAI 3-4 were classified as AS 1 (mild); those with only1 tooth and severity of PAI 5 as AS 2 (moderate) and those having > 2 tooth with severity of PAI 5 as AS 3 (severe). Blood samples were collected from all of the patients. Enzyme-linked immunosorbent assay was used to evaluate the samples. The MR-pro ADM levels of both the AP and P groups were considerably higher than the control group (p < 0.01). The IL-12 levels of the AP group were higher than the P and control groups (p < 0.05). TNF-alpha levels of the P group were significantly higher than both the AP and control groups (p < 0.01). MR-pro ADM levels of both the AP and Periodontitis groups were higher than the control group. TNF-alpha was a biomarker of periodontitis, while IL-12 was a biomarker of apical periodontitis.en_US
dc.identifier.citationErsahan, S., Ozcelik, F., Sirin, D. A., Hepsenoglu, Y. E., Ozcelik, I. K., & Topbas, C. (2022). Is adrenomedullin upregulation due to apical periodontitis independent of periodontal disease?. Odontology, 1-11.en_US
dc.identifier.doi10.1007/s10266-022-00767-9en_US
dc.identifier.issn1618-1247en_US
dc.identifier.issn1618-1255en_US
dc.identifier.scopus2-s2.0-85142229733en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttp://dx.doi.org/10.1007/s10266-022-00767-9
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3428
dc.identifier.wosWOS:000886450500001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzçelik, İlbey Kayra
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofODONTOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApical Periodontitisen_US
dc.subjectChronic Periodontitisen_US
dc.subjectMid Regional Proadrenomedullinen_US
dc.subjectIL-12en_US
dc.subjectTNF-Alphaen_US
dc.titleIs adrenomedullin upregulation due to apical periodontitis independent of periodontal disease?en_US
dc.typeArticleen_US

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