Contribution of bone marrow–derived mesenchymal stem cells to healing of pulmonary contusion-created rats

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dc.authoridErdal Karaöz / 0000-0002-9992-833Xen_US
dc.authorscopusidErdal Karaöz / 7003448087
dc.authorwosidErdal Karaöz / IXE-6677-2023
dc.contributor.authorDemir, Sabri
dc.contributor.authorErtürk, Ahmet
dc.contributor.authorGünal, Yasemin Dere
dc.contributor.authorÖzmen, İsmail
dc.contributor.authorZengin, Mehmet
dc.contributor.authorYıldız, Dinçer
dc.contributor.authorKaraöz, Erdal
dc.contributor.authorKarahan, Siyami
dc.contributor.authorŞenel, Emrah
dc.date.accessioned2021-01-19T07:46:06Z
dc.date.available2021-01-19T07:46:06Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: The most common thoracic injury in children, resulting in trauma, is pulmonary contusion (PC). Bone marrow–derived mesenchymal stem cells (BM-MSCs) are used in wound healing and many other diseases. This study aims to examine the effects of BM-MSCs on PC healing in rats. Materials and methods: A total of 45 male Wistar albino rats were used. Four groups were formed. BM-MSCs were labeled with the green fluorescent protein. PC was observed in the control group. In group II, PC occured and left to spontaneous healing. In group III, PC formed and BM-MSCs were given. In group IV, BM-MSCs were given without PC formation. Subjects were sacrificed 1 week later. Whether there was any difference in terms of BM-MSC involvement and lung injury score was investigated. Statistical analysis was performed using the Statistical Package for Social Sciences (SPSS), version 17.0, software (SPSS Inc., Chicago, IL), and p value of <0.05 was considered statistically significant. Results: BM-MSCs were collected much more in the lungs in group III than in group IV. Group III had a lower lung injury score value than group II. Conclusion: The greater involvement of the BM-MSCs in the injury site, and further reductions in lung injury score suggest that BM-MSCs are contributing to the healing of the injury. The use of BM-MSCs in risky patients with diffuse PC may be an alternative treatment to conventional methods.en_US
dc.identifier.citationDemir, S., Erturk, A., Gunal, Y. D., Ozmen, I., Zengin, M., Yildiz, D., ... & Senel, E. (2020). Contribution of Bone Marrow–Derived Mesenchymal Stem Cells to Healing of Pulmonary Contusion-Created Rats. Journal of Surgical Research, 261, 205-214.en_US
dc.identifier.doi10.1016/j.jss.2020.12.006en_US
dc.identifier.endpage214en_US
dc.identifier.issn0022-4804en_US
dc.identifier.pmid33450629en_US
dc.identifier.scopus2-s2.0-85099132758en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage205en_US
dc.identifier.urihttps://www.doi.org/10.1016/j.jss.2020.12.006
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1348
dc.identifier.volume261en_US
dc.identifier.wosWOS:000635161100027en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKaraöz, Erdal
dc.language.isoenen_US
dc.publisherAcademic Press Inc.en_US
dc.relation.ispartofJournal of Surgical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone Marrow-Derived Mesenchymal Stem Cellsen_US
dc.subjectChildrenen_US
dc.subjectPulmonary Contusionen_US
dc.subjectThoracic Injuryen_US
dc.subjectTraumaen_US
dc.titleContribution of bone marrow–derived mesenchymal stem cells to healing of pulmonary contusion-created ratsen_US
dc.typeArticleen_US

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