Anti-amoebic activity of a series of benzofuran/benzothiophene derivatives against acanthamoeba castellanii belonging to the T4 genotype

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dc.authoridNaveed Khan / 0000-0001-7667-8553en_US
dc.authoridRuqaiyyah Siddiqui / 0000-0001-9646-6208en_US
dc.authorscopusidRuqaiyyah Siddiqui / 18635417000en_US
dc.authorscopusidNaveed Ahmed Khan / 7401797675en_US
dc.authorwosidRuqaiyyah Siddiqui / FVT-1496-2022en_US
dc.authorwosidNaveed Ahmed Khan / FXL-5617-2022en_US
dc.contributor.authorAkbar, Noor
dc.contributor.authorEl-Gamal, Mohammed, I
dc.contributor.authorZaraei, Seyed-Omar
dc.contributor.authorSaeed, Balsam Qubais
dc.contributor.authorKhan, Naveed Ahmed
dc.contributor.authorSiddiqui, Ruqaiyyah
dc.date.accessioned2023-01-19T08:34:17Z
dc.date.available2023-01-19T08:34:17Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAims: To determine the anti-amoebic activity of benzofuran/benzothiophene-possessing compounds against Acanthamoeba castellanii of the T4 genotype. Method and results: A series of benzofuran/benzothiophene-possessing compounds were tested for their anti-amoebic activities, in particular, to block encystation and excystation processes in amoebae. Cytotoxicity of the compounds were evaluated using lactate dehydrogenase (LDH) assays. The amoebicidal assay results revealed significant anti-amoebic effects against A. castellanii. Compounds 1p and 1e showed the highest amoebicidal activity, eliminating 68% and 64% of the amoebae, respectively. These compounds remarkably repressed both the encystation and excystation processes in A. castellanii. Furthermore, the selected compounds presented minimal cytotoxic properties against human cells, as well as considerably abridged amoeba-mediated cytopathogenicity when compared to the amoebae alone. Conclusions: Our findings show that benzofuran/benzothiophene derivatives depict potent anti-amoebic activities; thus these compounds should be used as promising and novel agents in the rationale development of therapeutic strategies against Acanthamoeba infections.en_US
dc.identifier.citationAkbar, N., El-Gamal, M. I., Zaraei, S. O., Saeed, B. Q., Khan, N. A., & Siddiqui, R. (2022). Anti-amoebic activity of a series of benzofuran/benzothiophene derivatives against Acanthamoeba castellanii belonging to the T4 genotype. Journal of applied microbiology, lxac030. Advance online publication. https://doi.org/10.1093/jambio/lxac030en_US
dc.identifier.pmid36626774en_US
dc.identifier.scopus2-s2.0-85147457968en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttp://dx.doi.org/10.1093/jambio/lxac030
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3826
dc.identifier.wosWOS:000920229700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKhan, Naveed Ahmed
dc.institutionauthorSiddiqui, Ruqaiyyah
dc.language.isoenen_US
dc.relation.ispartofJ Appl Microbiolen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcanthamoeba Castellaniien_US
dc.subjectAmoebicidalen_US
dc.subjectAnti-Amoebic Activityen_US
dc.subjectCytopathogenicityen_US
dc.subjectCytotoxicityen_US
dc.subjectEncystationen_US
dc.subjectExcystationen_US
dc.titleAnti-amoebic activity of a series of benzofuran/benzothiophene derivatives against acanthamoeba castellanii belonging to the T4 genotypeen_US
dc.typeArticleen_US

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